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Journal Club Discussions

January 15, 2013

Regeneration capacity declines with age, but why juvenile organisms show enhanced tissue repair remains unexplained. Lin28a, a highly conserved RNA-binding protein expressed during embryogenesis, plays roles in development, pluripotency, and metabolism. To determine whether Lin28a might influence tissue repair in adults, we engineered the reactivation of Lin28a expression in several models of tissue injury. Lin28a reactivation improved hair regrowth by promoting anagen in hair follicles and accelerated regrowth of cartilage, bone, and mesenchyme after ear and digit injuries. Lin28a inhibits let-7 microRNA biogenesis; however, let-7 repression was necessary but insufficient to enhance repair. Lin28a bound to and enhanced the translation of mRNAs for several metabolic enzymes, thereby increasing glycolysis and oxidative phosphorylation (OxPhos). Lin28a-mediated enhancement of tissue repair was negated by OxPhos inhibition, whereas a pharmacologically induced increase in OxPhos enhanced repair. Thus, Lin28a enhances tissue repair in some adult tissues by reprogramming cellular bioenergetics.

Article Scan

April 14, 2014
The application of novel cell sorting technology allows the purification of cells based on electrophysiological properties, with studies correlating these properties to cell surface glycosylation.
April 14, 2014
The generation of an miRNA-mRNA interaction map in cells that make up the bone marrow niche allows regulatory pathways for signalling factors to be understood.

Stem Cell Buzz

November 30, 2013
November 30, 2013

Editors' Blog

by Lyle Armstrong

December 4,2013

We always wanted the STEM CELLS Portal to be a friendly, approachable, and above all easy-to-use resource. This is not always a simple goal given the vast and increasing volume of data related to stem cell research, but we hope we have improved the Portal sufficiently to encourage our existing users to make more use of the facility and to make it easier for new users to get involved.