Non-union defects of bone are a major problem in orthopedics, especially for patients with a low healing capacity. Autologous human bone marrow (hBM) is often used as a source for osteogenic stem cells, but efficacy is contingent on the healing capacity of the patients. Herein, this study shows that exposure of hBM to a glycogen-synthease-kinase inhibitor for a very short time, initiates an irreversible cascade that increases the osteogenic capacity of resident stem cells. Importantly, the BIO-treated hBM has the capacity to generate stronger and more compact fusion masses when tested in a rodent spine fusion model. This approach could represent a feasible and cost-effective strategy for functional enhancement of autologous hBM for orthopedic applications.
Resistance to treatment in non-small cell lung cancer is one of the major obstacles for clinicians. Recently, mutations in different genes have emerged as potential biomarkers of acquired resistance to treatment, however, little is known about the role of cancer stem cells. The present Review addresses how cancer stem cells can contribute to treatment resistance and how it can be overcome.
A new study establishes that the injection of a collagen-based biomaterial can mobilize endogenous stem cells to promote kidney regeneration in a mouse model