Featured Articles

Protein-Induced Pluripotent Stem Cells Ameliorate Cognitive Dysfunction and Reduce Aβ Deposition in a Mouse Model of Alzheimer’s Disease

Alzheimer's disease (AD) leads to cognitive dysfunctions without methods for cure or prevention. This study demonstrated that transplantation of protein-induced pluripotent stem cells (iPSCs) reduced plaque deposition and restored memory impairment in 5XFAD mice, an AD animal model. Also, the stem cell niche of these mice promotes differentiation of protein-iPSCs to glial cells, especially oligodendrocytes.

Local CXCR4 Upregulation in the Injured Arterial Wall Contributes to Intimal Hyperplasia

CXCR4 is a stem/progenitor cell surface receptor specific for the cytokine stromal cell-derived factor (SDF)-1 alpha. While previous studies show that blood-borne CXCR4-expressing progenitor cells contribute to intimal hyperplasia by homing to the arterial subintima which is enriched with SDF-1 alpha, it remains unclear whether CXCR4-expressing cells from other sources also play a role.


Journal Club Discussions

August 7, 2016

Research into glioblastoma multiforme brain tumors uncovers a potentially exciting new therapeutic target – myeloid-derived suppressor cells



Article Scans

August 22, 2016
A new study demonstrates that mesenchymal stem cells derived from cord blood could be an effective means to treat sepsis in human patients
August 22, 2016
Researchers discover that repletion of nicotinamide adenine dinucleotide (NAD+) may be an effective means to treat age-related degenerative disease
August 15, 2016
Unbiased transcriptomic and proteomic analysis provides the rational for an efficient dual targeting strategy to eradicate leukemic stem cells

Video Summary

Video abstract from Dr. Allen on his recently published STEM CELLS paper entitled, "Angiopellosis as an Alternative Mechanism of Cell Extravasation" Read the Paper here.

Video abstract from Drs. Serena, Keiran, Ceperuelo-Mallafre, Ejarque, Fradera, Roche, Nuñez-Roa, Vendrell, and Férnandez-Veledo on their recently published STEM CELLS paper entitled, "Obesity and Type 2 Diabetes Alters the Immune Properties of Human Adipose Derived Stem Cells" Read the Paper here.

Video abstract from Nobuyuki Sakayori, Takako Kikkawa, Hisanori Tokuda, Emiko Kiryu, Kaichi Yoshizaki, Hiroshi Kawashima, Tetsuya Yamada, Hiroyuki Arai, Jing X. Kang, Hideki Katagiri, Hiroshi Shibata, Sheila M. Innis, Makoto Arita and Noriko Osumi on their STEM CELLS paper entitled, "Maternal dietary imbalance between omega-6 and omega-3 polyunsaturated fatty acids impairs neocortical development via epoxy metabolites." Read the paper here.

Graphical Abstracts

Isolation and directed differentiation of salivary human stem/progenitor cells (hS/PCs) into salivary acinar-like cells.  An ex vivo culture system used to isolate scalable quantities of hS/PCs with consistent expression of progenitor markers, is reported here.  These hS/PCs can be maintained in long-term culture in 2D or in 3D, without loss of stem/progenitor markers.  Incorporation of bioactive basement membrane-derived peptides in the 3D hyaluronate (HA) hydrogel culture system enhances progenitor expansion.  Stimulation of hS/PC spheroids with neurotransmitter agonists leads to differentiation toward an acinar lineage.  

Stem cells are emerging as a scientifically plausible treatment and possible cure for cerebral palsy, but are not yet proven. The lack of valid animal models has significantly hampered the scope of clinical trials. Despite the state of current treatment evidence, parents remain optimistic about the potential improvements from stem cell intervention and feel compelled to exhaust all therapeutic options, including stem cell tourism. Receiving unproven therapies from unvalidated sources is potentially dangerous. Thus it is essential that researchers and clinicians stay up to date. A systematic review and meta-analysis summarizing and aggregating current research data may provide more conclusive evidence to inform treatment decision making and help direct future research.

At 1 hour post- traumatic spinal cord injury (SCI), 2.5 million human stromal cells (human umbilical cord matrix cells, HUCMCs; or human brain vascular pericytes, HBVPs) were systemically infused via the tail vein (A). While a majority of cells ended up in the lungs, liver and spleen, the spleen was found to be the site of IL-10 synthesis/release (B). Systemic changes in IL-10 were associated with decreased blood-spinal cord barrier (BSCB) permeability and reduced spinal cord hemorrhage at acute time-points (C). Weekly-standardized behavioural testing revealed that the early protective effects of cell infusion lead to some improvements in functional recovery (D). Together, these data warrant further study of the splenic role in secondary pathology and cell-based reparative mechanisms for future clinical translation.