Featured Articles


Concise Review: Therapeutic Potential of the Mesenchymal Stem Cell Derived Secretome and Extracellular Vesicles for Radiation‐Induced Lung Injury: Progress and Hypotheses

Although it has been reported that soluble cytokines based on mesenchymal stem cells (MSCs) therapy that could attenuate radiation‐induced lung injury (RILI), the mechanism of MSC‐based secretome therapy for RILI is still not fully understood. This review summarized the recent progress regarding the potential mechanisms of MSCs therapy for RILI, with an emphasis on MSC‐secreted cytokines and miRNAs as a safe and, effective cell‐free therapy, which may be helpful to accelerate the strategy from bench to bedside.


Human Multipotent Stromal Cell Secreted Effectors Accelerate Islet Regeneration

Cell‐based therapies using human multipotent stromal cells (hMSC) to dampen autoimmunity while inducing islet regeneration represents a promising approach to treat diabetes. However, poor survival and retention of transplanted hMSC in the damaged pancreas complicates clinical translation. The research demonstrated that hMSC secrete an array of islet‐regenerative proteins and intrapancreatic delivery of hMSC‐conditioned media (CM) could stimulate islet regeneration without the need for cell transfer. Wnt‐pathway stimulated hMSC CM‐injection set in motion a cascade of events consistent with the emergence of functional islets. Discovery of hMSC‐secreted, islet‐regenerative effectors may lead to the development of cell‐free therapies to combat diabetes.

 

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April 1, 2019

Research identifies hBM-MSC derived factors that promote islet regenerative and may permit the development of cell‐free therapies for diabetic patients

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Article Scans

April 15, 2019
Systematic evaluation of methods to differentiate dopaminergic neurons from hPSCs identifies measures to improve comparisons and clinical translation
April 15, 2019
Researchers investigate the hypothesis that hyperglycemia may influence autophagy in neural stem cells and that melatonin may act as a protective agent
April 15, 2019
Activation of retrotransposons contributes to inflammaging, although the L1 reverse transcriptase represents a target for age-associated disorder treatment