Current studies revealed the promising therapeutic mechanisms in Inflammatory Bowel Disease by which Mesenchymal Stem Cells (MSC) modulate not only an immunological action but also a regenerative effect on the intestinal epithelium normalization. The routine use of MSC cellular therapy with would benefit from a uniform cell source, with stable phenotype and function as well as providing a solution to potential safety issues. Therefore, this work provides strong support for the use of iPSC‐derived MSC as a more uniform with well‐defined phenotype and function as a sustainable source of cells which paves the way for a clinical application for IBD cellular therapy.
Mesenchymal Stem Cells (MSC) Derived from Induced Pluripotent Stem Cells (iPSC) Equivalent to Adipose‐Derived MSC in Promoting Intestinal Healing and Microbiome Normalization in Mouse Inflammatory Bowel Disease Model
Precise regulation of muscle satellite cells (SCs) quiescence, proliferation, and differentiation is crucial for muscle homeostasis. This study reports on an important role for transcription factor FoxM1 in the maintenance of SCs. Deregulation of FoxM1 expression led to impaired proliferation and survival of SCs. Data further suggested that the FoxM1-Snhg8 and FoxM-Gm26917 axis sustains the proliferation and survival of SCs in a tissue-specific manner. The study uncovered long noncoding RNA genes that are regulated by FoxM1, and provides insights into the molecular network of SCs regulation.
New research demonstrates that immune cells help to mediate, distribute, and transfer the immunomodulatory effects of mesenchymal stem cells following systemic administration