Featured Articles

Autologous Cord Blood Infusions Are Safe and Feasible in Young Children with Autism Spectrum Disorder: Results of a Single‐Center Phase I Open‐Label Trial

This phase I study demonstrates that it is safe and feasible to perform autologous umbilical cord blood infusions in young children with autism spectrum disorder and identifies several promising outcome measures for use in future trials.

Read the related CNN Article.



Quaking Is a Key Regulator of Endothelial Cell Differentiation, Neovascularization, and Angiogenesis

Cardiovascular disease is a leading cause of mortality worldwide with pathology being driven by the dysfunction of endothelial cells (ECs). Induced pluripotent stem (iPS) cell technology is offering new avenues to generate ECs. Although there has been significant progression in the field, currently, there are not any fully defined protocols in existence aimed at generating high-fidelity, stable ECs. We provide robust evidence that the RNA-binding protein QKI has a unique role in inducing EC differentiation from iPS cells and remarkably improving angiogenesis, neovascularization and blood flow recovery (almost 100%) in an in vivo model of vascular regeneration.

 

Journal Club Discussions

April 9, 2017

A new study describes an improved protocol for the efficient differentiation of endothelial cells from pluripotent stem cell sources and highlights the importance of the MAPK and PI3K signaling pathways

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Article Scans

April 29, 2017
A new study describing the magnetic sorting of smooth muscle progenitor cells derived from human induced pluripotent stem cells may promote their clinical application
April 29, 2017
The overexpression of an RNA binding protein enhances endothelial cell differentiation from induced pluripotent stem cells and may improve the treatment of cardiovascular disease patients
April 23, 2017
A new study suggests that bone marrow derived mononuclear cells could represent a safe and effective treatment for severe traumatic brain injury

Video Summary

Video abstract from Drs. Cox, Hetz, Liao, Aertker, Ewing-Cobbs, Juranek, Savitz, Jackson, Romanowska-Pawliczek, Triolo, Dash, Pedroza, Lee, Worth, Aisiku, Choi, Holcomb, and Kitagawa on their recently published STEM CELLS paper entitled, "Treatment of Severe Adult Traumatic Brain Injury Using Bone Marrow Mononuclear Cells." Read the paper here.

Video abstract from Dr. Cooke, et al. on his recently published STEM CELLS paper entitled, "Retinoic Acid Inducible Gene 1 Protein (RIG1)-like Receptor Pathway is Required for Efficient Nuclear Reprogramming" Read the paper here.

Video abstract from Dr. Hochane et al. on his recently published STEM CELLS paper entitled, "Low-Dose Pesticide Mixture Induces Senescence in Normal Mesenchymal Stem Cells (MSC) and Promotes Tumorigenic Phenotype in Premalignant MSC." Read the paper here.

Graphical Abstracts

Confocal picture showing the myelinogenic potential of hiPS-NSCs engrafted at the border between the striatum and the corpus callosum of immunodeficient MLD mice at 3 months post-transplantation(green, human cells labeled with anti-human mitochondria; red, myelin basic protein; blue, nuclei counterstained with ToPro3). Scale bar: 100µm.

An ex vivo culture system used to isolate scalable quantities of hS/PCs with consistent expression of progenitor markers, is reported here. These hS/PCs can be maintained in long-term culture in 2D or in 3D, without loss of stem/progenitor markers.  Incorporation of bioactive basement membrane-derived peptides in the 3D hyaluronate (HA) hydrogel culture system enhances progenitor expansion.  Stimulation of hS/PC spheroids with neurotransmitter agonists leads to differentiation toward an acinar lineage.

Stem cells are emerging as a scientifically plausible treatment and possible cure for cerebral palsy, but are not yet proven. The lack of valid animal models has significantly hampered the scope of clinical trials. Despite the state of current treatment evidence, parents remain optimistic about the potential improvements from stem cell intervention and feel compelled to exhaust all therapeutic options, including stem cell tourism. Receiving unproven therapies from unvalidated sources is potentially dangerous. Thus it is essential that researchers and clinicians stay up to date. A systematic review and meta-analysis summarizing and aggregating current research data may provide more conclusive evidence to inform treatment decision making and help direct future research.