Featured Articles

Concise Review: Developing Best‐Practice Models for the Therapeutic Use of Extracellular Vesicles

Extracellular vesicles (EVs) have been implicated as important and sometimes sufficient mediators of the effects of stem cells. Best-practice models must be developed for the rapid development of exosomes, microvesicles, and other EVs as therapeutic entities.



Concise Review: Mesenchymal Stem Cells in Neurodegenerative Diseases

Mesenchymal stem cells (MSCs) hold great potential as source for cell-based therapy for neurodegenerative diseases. In this review, we summarize recent progress using human MSC transplantation into rodent models of neurodegeneration. We examine the molecular mechanisms mediating disease amelioration through this approach and emphasize the potential of ex vivo manipulation for these cells before transplantation.

 

Journal Club Discussions

July 3, 2017

Researchers studying the effects of iPSC-MSCs treatment in an in vivo mouse model discover a novel immunomodulatory mechanism involving caspase proteins

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Article Scans

July 23, 2017
New research indicates that placental stem cell engraftment may represent an interesting new strategy to treat an enzyme deficiency associated with a lysosomal storage disorder
July 23, 2017
Two exciting technologies collide to facilitate the modeling of a rare genetic disease and provide a means to discover new treatment strategies
July 16, 2017
Studies into sex determination using induced pluripotent stem cells leads to a potential strategy to conserve an endangered species