Featured Articles


Chondroitin Sulfate Immobilized on a Biomimetic Scaffold Modulates Inflammation While Driving Chondrogenesis

Recently, increasing clinical evidence has highlighted the important role of proinflammatory mediators and infiltrating inflammatory cell populations inducing chronic inflammation and diseases in damaged cartilage. This work should be of broad interest because it proposes an implantable biomimetic material, which holds the promise for a variety of medical conditions that necessitate the functional restoration of damaged cartilage tissue (such as trauma, diseases, deformities, or cancer).



Human Embryonic Stem Cells—What Have We Done? What Are We Doing? Where Are We Going?

hESC-based therapies have now become a reality. However, the development of HLA-homozygous iPSC banks, such as the one in Japan provide an ethically neutral alternative to hESC for therapeutic as well as research applications. International guidelines on screening and application of these iPSC lines will likely lead to complete redundancy of hESC lines at some point in the future.

 

Journal Club Discussions

July 10, 2016

A new study suggests that overexpression of SDF1α leads to enhanced stem cell-based cardiac repair of the infarcted heart

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Article Scans

July 24, 2016
Researchers underline the importance of donor age in human cardiac progenitor cell therapy in a mouse model
July 24, 2016
Researchers find that the somatic expression of the Oct4 pluripotency gene is linked to the function of smooth muscle cells and the resolution of atherosclerotic plaques
July 17, 2016
New cell cycle studies of the human embryonic stem cells suggests that a G2 pause is required for lineage-specific differentiation

Video Summary

Video abstract from Dr. Allen on his recently published STEM CELLS paper entitled, "Angiopellosis as an Alternative Mechanism of Cell Extravasation" Read the Paper here.

Video abstract from Drs. Serena, Keiran, Ceperuelo-Mallafre, Ejarque, Fradera, Roche, Nuñez-Roa, Vendrell, and Férnandez-Veledo on their recently published STEM CELLS paper entitled, "Obesity and Type 2 Diabetes Alters the Immune Properties of Human Adipose Derived Stem Cells" Read the Paper here.

Video abstract from Nobuyuki Sakayori, Takako Kikkawa, Hisanori Tokuda, Emiko Kiryu, Kaichi Yoshizaki, Hiroshi Kawashima, Tetsuya Yamada, Hiroyuki Arai, Jing X. Kang, Hideki Katagiri, Hiroshi Shibata, Sheila M. Innis, Makoto Arita and Noriko Osumi on their STEM CELLS paper entitled, "Maternal dietary imbalance between omega-6 and omega-3 polyunsaturated fatty acids impairs neocortical development via epoxy metabolites." Read the paper here.

Graphical Abstracts

Stem cells are emerging as a scientifically plausible treatment and possible cure for cerebral palsy, but are not yet proven. The lack of valid animal models has significantly hampered the scope of clinical trials. Despite the state of current treatment evidence, parents remain optimistic about the potential improvements from stem cell intervention and feel compelled to exhaust all therapeutic options, including stem cell tourism. Receiving unproven therapies from unvalidated sources is potentially dangerous. Thus it is essential that researchers and clinicians stay up to date. A systematic review and meta-analysis summarizing and aggregating current research data may provide more conclusive evidence to inform treatment decision making and help direct future research.

At 1 hour post- traumatic spinal cord injury (SCI), 2.5 million human stromal cells (human umbilical cord matrix cells, HUCMCs; or human brain vascular pericytes, HBVPs) were systemically infused via the tail vein (A). While a majority of cells ended up in the lungs, liver and spleen, the spleen was found to be the site of IL-10 synthesis/release (B). Systemic changes in IL-10 were associated with decreased blood-spinal cord barrier (BSCB) permeability and reduced spinal cord hemorrhage at acute time-points (C). Weekly-standardized behavioural testing revealed that the early protective effects of cell infusion lead to some improvements in functional recovery (D). Together, these data warrant further study of the splenic role in secondary pathology and cell-based reparative mechanisms for future clinical translation.

Brown adipose pads are present in the interscapular region of human fetus. Tissue sections from a representative fetus (12 week gestation). Hematoxylin-eosin staining of fetal interscapular adipose tissue revealed the presence of some dispersed cells with a multilocular aspect, characteristic of brown adipocytes (A–C, arrowheads). Immunohistochemistry on serial sections confirmed the brown nature of the multilocular cells which were positive for the brown marker uncoupling-protein-1 (UCP-1) (E–F). Negative control with unstained multilocular cells (D, arrowheads). Magnification: (A): × 10; (B, D, E): × 20; (C): × 40; (F): × 60.