Featured Articles


Using Fat to Fight Disease: A Systematic Review of Non‐Homologous Adipose‐Derived Stromal/Stem Cell Therapies

Stem cell therapy has shown potential benefit in a variety of human diseases. However, there are limitations to the widespread clinical application including the use of invasive procedures to isolate cells and the need for processing. Adipose-derived stromal/stem cells (ASC) are adult cells that possess the capacity for homing, immunomodulation, promotion of repair, and direct regeneration of damaged tissues, which make them promising therapeutic candidates. Furthermore, these cells can be easily obtained in large quantities from subcutaneous tissue, allowing for an abundance of cells to be isolated relatively easily.



Topical Application of Culture‐Expanded CD34+ Umbilical Cord Blood Cells from Frozen Units Accelerates Healing of Diabetic Skin Wounds in Mice

This study demonstrates that therapeutic cells from frozen umbilical cord units can be expanded ex vivo and retain their therapeutic properties. The cells were used to treat diabetic skin ulcers and demonstrated faster wound closure and improved skin regeneration compared to controls.

 

Journal Club Discussions

April 30, 2018

Combined treatment of spinal cord injury with adipose-derived stem cells and olfactory ensheathing cells leads to high levels of repair in a rat model

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Article Scans

May 21, 2018
Researchers demonstrate that epigenetic silencing of TAP genes in breast cancer stem cells play a crucial role in immune evasion mechanisms
May 21, 2018
A new report describes how a novel culture system boosts the regenerative properties of diabetic endothelial progenitor cells and improves wound healing
May 14, 2018
A new study from the Knoepfler laboratory reveals EBP1 as a major cofactor that influences the transcriptional activity of DPPA4 in pluripotent cells