Human Embryonic Stem Cell Differentiation Toward Regional Specific Neural Precursors

Slaven Erceg, Mohammad Ronaghi, Miodrag Stojkovic

Stem Cells Express, first published online October 9, 2008; doi:10.1634/stemcells.2008-0543

ABSTRACT

Human embryonic stem cells (hESC) are self renewing pluripotent cells which have the capacity to differentiate into a wide variety of cell types. This potentiality represents a promising source to overcome many human diseases by providing an unlimited supply of all cell types including cells with neural characteristics. Therefore, this review summarises early neural development and potential of hESC to differentiate under in vitro conditions examining at the same time the potential use of differentiated hESC for therapeutic applications for neural tissue and cell regeneration.

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