Institute of Medical Biology

	Dr. Barbara Knowles and Dr. Davor Solter are the Senior Principle Investigators of the Mammalian Development Laboratory at the Institute of Medical Biology in Singapore. Their research areas include oocyte-to-embryo transition, reprogramming, and mouse/human embryonic stem cell differentiation.

“Unraveling the molecular complexity that underlies plasticity between the embryonic stem cell/differentiated cell state has become one of the major scientific themes of our time. The transcriptome, the signal transduction mechanisms regulating its stability and translation, and chromatin modifications are inter-related mechanisms that control this change of cell fate. In earlier times we investigated cell surface molecules and extracellular matrix changes accompanying embryonic stem cell differentiation. In recent years we have focused on the oocyte-to-embryo transition, gaining knowledge of the transcriptome and molecular processes that govern activation of the embryonic genome. We now propose to reciprocally study these processes in vivo in mouse oocytes and embryos and in vitro in human and mouse embryonic stem cells.”

Contact Information:
Institute of Medical Biology
8A Biomedical Grove, #06-06 Immunos,
Singapore 138648
Tel: (65) 6407 0172

Dr. Barbara Knowles
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Dr. Davor Solter
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Mammalian Development Laboratory Homepage
Research
Group Members

Barbara Knowles’ Homepage
Biography of Dr. Knowles
Representative Publications

Davor Solter’s Homepage
Biography of Dr. Solter
Representative Publications

About the Institute of Medical Biology

About A*STAR

Singapore Stem Cell Bank (SSCB)

Singapore Stem Cell Consortium (SSCC)

Stem Cell Society Singapore (SCSS)

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