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Dr. Konrad Hochedlinger's Lab

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Contact Information:
Department of Medicine, Harvard Medical School
Department of Stem Cell and Regenerative Biology, Harvard University
Cancer Center and Center for Regenerative Medicine
Massachusetts General Hospital
Richard B. Simches Building, CPZN 4242
185 Cambridge St.
Boston, MA 02114
Tel: 617-643-2075
Fax: 617-724-2662
Email: khochedlinger@helix.mgh.harvard.edu
Summary of Research in the Hochedlinger Lab

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Our lab tries to understand the molecular mechanisms underlying pluripotency and nuclear reprogramming. Pluripotency denotes the ability of cells, such as embryonic stem (ES) cells, to give rise to all cell types of the mammalian body, while nuclear reprogramming is the dedifferentiation of a specialized cell back into a pluripotent state. Reprogramming does not normally occur in vivo but can be achieved experimentally by nuclear transfer, ES cell-somatic cell fusion and by directly inducing embryonic genes in somatic cells, generating so-called induced pluripotent (iPS) stem cells.

We are studying these processes functionally by establishing transgenic and knock-out mice and by manipulating murine and human ES cells. Combined with genome-wide approaches including RNAi and chemical screening we aim to dissect the mechanisms of pluripotency and epigenetic reprogramming. Ultimately, we hope that our research will aid in attempts to generate custom-tailored cells for treating and understanding disease.

Hochedlinger Lab Homepage

The Center for Regenerative Medicine at Massachusetts General Hospital

Centre for Cancer Research at Massachusetts General Hospital

Massachusetts General Hospital Homepage

Hochedlinger Homepage at Harvard University

Department of Biological and Biomedical Sciences, Harvard University

Harvard Stem Cell Institute

Harvard University Homepage

Publications

Hochedinger Lab Plasmids

Patents

Dr. Hochedlinger in the News

Department of Stem Cell and Regenerative Biology