You are hereAugust 6, 2009
Dr. Rudolf Jaenisch's Lab
Rudolf Jaenisch, M.D.
Nine Cambridge Center
Assistant: Gerry Kemske
Celebrating 10 Years of hESC Cell Lines
Ten years ago this November, a paper was published that led to an explosion in the field of stem cell research. In November 1998, Dr. James Thomson’s laboratory reported the first derivation of
human embryonic stem cell (hESC) lines from human blastocysts (Science 1998;282:1145–1147).
To celebrate this landmark discovery, and to look forward to the future of stem cell research, Stem Cells has begun an interview series titled “Celebrating 10 Years of hESC Cell Lines”. Over the next several months, STEM CELLS will present interviews reflecting on the lives and achievements of some of the premiere scientists in the field of stem cells and Regenerative Medicine. The series continues here with “An Interview with Rudolf Jaenisch”.
Read additional excerpts from our interview with Dr. Jaenisch available only on the Stem Cells Portal
Join our Discussion Forum - "With the advent of iPS cells, is generating ESCs from embryos still important?"
Overview of the Jaenisch Lab:
“What makes a given cell a given cell—what makes a liver cell a liver cell versus a brain cell versus an embryonic cell?” asks Rudolf Jaenisch. “We want to understand this in molecular terms, and we are using this information to convert one cell type into another.”
Jaenisch, a Whitehead Founding Member, focuses on understanding epigenetic regulation of gene expression (the biological mechanisms that affect how genetic information is converted into cell structures but that don’t alter the genes in the process). Most recently, this work has led to major advances in our understanding of embryonic stem cells and “induced pluripotent stem” (IPS) cells, which appear identical to embryonic stem cells but can be created from adult cells without using an egg.