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iPSC’s “Memory” Suggests Limited Use Compared to ESC

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Two advance articles in Nature and Nature Biotechnology from the labs of Konrad Hochedlinger, George Daley and Andrew Feinberg have suggested that iPSC retain a “memory” of their initial state, and therefore may be of limited use in regenerative medicine. When studying murine iPSC, it was found that the epigenetic profile of the mouse donor cell wasn’t entirely “erased” and the differentiation potential of the iPSC was linked to the cell of origin. Further analysis of this type in human iPSC may decide whether iPSC technology as we know it will be a suitable replacement for hESC derivation.

Also see the following news items from BusinessWeek, Nature and The-Scientist.