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Potential Stem Cell Therapy for HIV Reported

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Potential Stem Cell Therapy for HIV Reported

From Nature Biotech

An advance online article from Nature Biotechnology reports the creation of genetically modified human hematopoietic stem/progenitor cells which when injected and engrafted in mice confer some resistance to HIV.   Specifically, Holt et al disrupted CCR5, the major HIV-1 co-receptor using engineered zinc-finger nucleases (ZFNs) and compared to control mice, the mice which received such cells showed significantly lower HIV-1 levels.