Featured Articles

Preclinical Evaluation and Optimization of a Cell Therapy Using Human Cord Blood‐Derived Endothelial Colony‐Forming Cells for Ischemic Retinopathies

The capacity of endothelial colony-forming cells (ECFCs) to promote vascular repair and regeneration of the ischemic retina has potential for clinical translation; however, cell transplantation into the eye requires extensive preclinical testing. This study provides supporting evidence to facilitate effective translation into clinics. The authors demonstrated high purity of the ECFC cell product, minimal therapeutic dose, and efficacy using readouts that include in vivo angiography. Toxicity was not observed after ECFC intravitreal delivery into healthy adult eyes. Importantly, this study also showed feasibility of intracarotid delivery for targeting the ipsilateral retina.



Concise Review: The Use of Stem Cells for Understanding and Treating Huntington's Disease

This review covers the important role stem cells play in understanding and treating Huntington's disease (HD). The significance of the review is the comprehensive discussion of the range of applications by which stem cells can be applied to HD research and therapy, including manipulation of either endogenous or exogenous stem cell populations. In particular, the advantages and disadvantages of using induced pluripotent stem cells compared with directly reprogrammed neural stem cells for cell replacement therapy is discussed. Furthermore, the therapeutic potential of mesenchymal stem cells is identified. Potential gaps in knowledge and future directions are specifically delineated.

 

Journal Club Discussions

December 11, 2017

Researchers demonstrate the possibility of enhanced tooth repair via the application of Platelet-Derived Growth Factor-modified human dental pulp stem cells 

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Article Scans

December 11, 2017
A new computerized technique based on morphological assessments may lead to increases in the efficiency of induced pluripotent stem cell reprogramming strategies 
December 11, 2017
Researchers discover that extracellular vesicles derived from MSCs rescue HSCs from the effects of irradiation and may represent a new therapeutic option
November 20, 2017
A new mouse study demonstrates how intravenous endometrial regenerative cell-treatment could improve tolerance of transplants via the expression of SDF-1