Patients with diabetes mellitus who suffer a stroke have worse neurological outcomes and long-term functional recovery than nondiabetic stroke patients. Given the differential challenges of treating strokes in diabetics compared to nondiabetics, this perspective summarizes current knowledge and highlights promising cell based and exosome therapy for diabetic stroke.
Mesenchymal stem cells (MSC) may be used to for therapy by injection into the blood. However, little is known about the behavior of MSC in flowing blood and subsequent adhesion in blood vessels. We show that the adhesive behavior of flowing MSC depends on their origin because this influences how they interact with platelets also found in the blood. MSC from umbilical cords induce platelet activation which could cause clots to form. The platelets also influence how all MSC stick to surfaces, which could affect their deposition in damaged tissues. The results have implications for therapeutic infusion of MSC.
Researchers discover that treatment with microvesicles from young MSCs can rejuvenate aged HSCs and potentially improve bone marrow transplantation outcomes