Featured Articles

Cell‐Based and Exosome Therapy in Diabetic Stroke

Patients with diabetes mellitus who suffer a stroke have worse neurological outcomes and long-term functional recovery than nondiabetic stroke patients. Given the differential challenges of treating strokes in diabetics compared to nondiabetics, this perspective summarizes current knowledge and highlights promising cell based and exosome therapy for diabetic stroke.

Origin‐specific Adhesive Interactions of Mesenchymal Stem Cells with Platelets Influence their Behaviour After Infusion

Mesenchymal stem cells (MSC) may be used to for therapy by injection into the blood. However, little is known about the behavior of MSC in flowing blood and subsequent adhesion in blood vessels. We show that the adhesive behavior of flowing MSC depends on their origin because this influences how they interact with platelets also found in the blood. MSC from umbilical cords induce platelet activation which could cause clots to form. The platelets also influence how all MSC stick to surfaces, which could affect their deposition in damaged tissues. The results have implications for therapeutic infusion of MSC.


Journal Club Discussions

March 4, 2018

Researchers discover that treatment with microvesicles from young MSCs can rejuvenate aged HSCs and potentially improve bone marrow transplantation outcomes



Article Scans

March 19, 2018
A new study identifies a long non-coding RNA as an important barrier impeding the reprogramming of cells derived from old patients
March 19, 2018
A new study suggests that DNA methylation analysis of select gene promoters can identify the optimal pluripotent stem cell for bone repair strategies
March 12, 2018
A new study from University of Tampere, Finland suggests that human adipose stem cells injection represent a simple and feasible treatment option for anal sphincter muscle injury