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Brief reviews of recently published articles, organized by stem cell type.

December 10, 2012 | Pluripotent Stem Cells

While the overexpression of specific transcription factors in embryonic stem cells (ESCs) can allowed the production of specific cell types such as haematopoietic stem/progenitor cells, adipocytes and neural progenitors, our ability to form functional artificial organs from these cells is still limited (Eiraku et al, Eiraku and Sasai, and Suga et al). Now, in a study...

December 10, 2012 | Pluripotent Stem Cells

Original article from STEM CELLS

“Cellular Heterogeneity During Embryonic Stem Cell Differentiation to Epiblast Stem Cells Is Revealed by the ShcD/RaLP Adaptor Protein”

The Shc (Src homolog and collagen homolog) family of adaptor proteins is a crucial linker of a wide range of receptors to their downstream...

November 15, 2012 | Pluripotent Stem Cells

Original article from STEM CELLS Translational Medicine

“Apoptotic Susceptibility to DNA Damage of Pluripotent Stem Cells Facilitates Pharmacologic Purging of Teratoma Risk”

The potential for dysregulated cell growth and teratoma formation after the transplantation of embryonic stem cell (ESC)- or induced pluripotent stem cell (iPSC)-...

November 6, 2012 | Pluripotent Stem Cells

“Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2”

The inner mechanics of the processes which take place during the reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) are gradually being delineated. One of the most important aspects of the reprogramming process is erasure of the somatic epigenetic pattern and the establishment...

November 6, 2012 | Pluripotent Stem Cells

“Direct Differentiation of Human Pluripotent Stem Cells into Haploid Spermatogenic Cells”

For adult and prepubescent patients who have been rendered sterile, no treatments to restore fertility are currently available. Multiple studies have however shown the ability of embryonic stem cells (ESCs) to be differentiated to primordial germ cells (PGCs), precursors of the spermatogenic...

November 5, 2012 | Pluripotent Stem Cells

“Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein”

Previous attempts to differentiate human pluripotent cells into lung epithelia have generated mixed results; studies in human embryonic stem cells (hESCs) have produced cells that express distal airway epithelial phenotypes at low efficiency (Van Haute et al...

November 5, 2012 |

“Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein”

Previous attempts to differentiate human pluripotent cells into lung epithelia have generated mixed results; studies in human embryonic stem cells (hESCs) have produced cells that express distal airway epithelial phenotypes at low efficiency (Van Haute et al...

October 22, 2012 | Direct Reprogramming

Findings published on October 4th 2012 in Cell Stem Cell, have shown it is possible to reprogramme mouse and human pericytes, brain cells typically found surrounding the endothelial cells of the brain’s capillary network, into neurons. The results from Benedikt Berninger’s group at the Ludwig-Maximilians University Munich could have potential therapeutic implications for patients with...

October 22, 2012 | Pluripotent Stem Cells

Original article from STEM CELLS

“Regulation and Expression of the ATP-Binding Cassette Transporter ABCG2 in Human Embryonic Stem Cells”

ATP-binding cassette sub-family G member 2 (ABCG2) is known to function as a multidrug efflux pump and plays a role in resistance to chemotherapeutic agents in cancer cells. While it has been implicated...

October 22, 2012 | Ependymal Stem Cells

Original article from STEM CELLS

“FM19G11 Favors Spinal Cord Injury Regeneration and Stem Cell Self-Renewal by Mitochondrial Uncoupling and Glucose Metabolism Induction”

Activation of resident adult stem/progenitor cells for the treatment of some disease/injury states is often seen as a viable alternative to the transplantation of...

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