You are here

Article Scans

Comment

Discuss

Brief reviews of recently published articles, organized by stem cell type.

May 20, 2012 | Pluripotent Stem Cells

From Stem Cells
By Stuart P. Atkinson

Amongst the factors that are know to maintain pluripotent cell types, factors in the FGF pathway are perhaps the most important, as they have been implicated in cell survival, proliferation, pluripotency, and lineage determination during differentiation (Eisellova et al, Lanner and Rossant, Levenstein et al, Vallier...

May 20, 2012 | Pluripotent Stem Cells

From Stem Cells
By Stuart P. Atkinson

Protocols for the production of hepatocytes and insulin-secreting pancreatic beta cells from human embryonic stem cells (hESCs) for treatment of disease and injury, begins with the production of definitive endoderm (DE), but while factors such as Activin A, which activates SMAD2/3, FGF, WNT and BMP (Arnold and Robertson, and Tam and...

May 18, 2012 | Neural Stem Cells

‘Implantation site and lesion topology determine efficacy of a human neural stem cell line in a rat model of chronic stroke’

From Stem Cells
Commentary by Carla B. Mellough

Stroke remains one of the leading causes of mortality and adult disability in developed nations1-3. For the survivors of stroke, the resulting disability is often persistent in nature...

March 30, 2012 | Pluripotent Stem Cells

From Stem Cells
By Stuart P. Atkinson

Multiple studies in the last few years have attempted the production of induced pluripotent stem cells (iPSCs) with a reduced set of reprogramming factors (from OCT4, SOX2, KLF4, MYC or OCT4, SOX2, LIN28 and NANOG) in order that the process becomes streamlined in the hope that this may reduce potential mutation load in the resultant...

March 30, 2012 | Pluripotent Stem Cells

From Stem Cells
By Stuart P. Atkinson

Recent studies in the field of induced pluripotent stem cells (iPSCs) through karyotypic (Taapken et al) and meta-analysis of gene expression data (Mayshar et al) have revealed aneuploidy, and also copy number analysis has detected large-scale sub-chromosomal aberrations (Laurent­­ et al and Martins-Taylor...

March 30, 2012 | Cancer Stem Cells

From Stem Cells
By Stuart P. Atkinson

Several recent studies (Ben-Porath et al, Somervaille et al and Wong et al) have identified ESC-like gene expression patterns in a variety of malignant tumors suggesting a molecular relationship between aggressive cancers and pluripotency. However, the molecular determinants of such a link have yet to be...

March 26, 2012 |

The University of Michigan's first human embryonic stem cell line will be placed on the U.S. National Institutes of Health's registry, making the cells available for federally funded research. The university is among just a handful of U.S. universities creating human embryonic stem cell lines. There are only 147 stem cell lines currently available on the registry.

The line, known as UM4...

March 26, 2012 | Pluripotent Stem Cells

The University of Michigan's first human embryonic stem cell line will be placed on the U.S. National Institutes of Health's registry, making the cells available for federally funded research. The university is among just a handful of U.S. universities creating human embryonic stem cell lines. There are only 147 stem cell lines currently available on the registry.

The line, known as UM4...

March 26, 2012 | Cord Blood Stem Cells

A new stem cell study may offer hope for patients suffering from one of the most common causes of childhood deafness.

Sensorineural hearing loss (SNHL) occurs when there is damage to the cochlea or the nerve pathways from the inner ear to the brain. The American Speech-Language Hearing Association says the causes of SNHL can range from genetics and head trauma to drugs, illnesses and...

March 7, 2012 | Pluripotent Stem Cells

The attainment of pluripotency during development has been linked to genome-wide epigenetic changes, such as DNA methylation and histone modifications, and also to the expression of key genes, such as Oct4 and Nanog (Chambers et al, Mitsui et al, Nichols et al and Reik). However, details on how such epigenetic changes affect key pluripotency-associated gene...

Pages