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Brief reviews of recently published articles, organized by stem cell type.

June 4, 2012 | Pluripotent Stem Cells

 

Other than purity and optimal functionality, one of the main concerns with the transplantation of embryonic stem cell (ESC)- or induced pluripotent stem cell (iPSC)-derived cells is their potential tumourigenicity in vivo. To address this, researchers from the group of Jun Takahashi from Kyoto University, Japan studied the effect of transplantation of neural progenitor cells...

June 4, 2012 | Pluripotent Stem Cells

 

Neural stem cell (NSC)-based cancer therapeutics show great potential as while they display an inherent tropism for sites of brain injury they also effectively target sites of tumourigenesis through as yet unappreciated mechanisms (Aboody et al 2000 and Aboody et al 2008). For this reason NSCs could be utilised in gene therapy strategies against various types of...

May 31, 2012 | Pluripotent Stem Cells

From Nature 
By Stuart P. Atkinson

Cellular reprogramming through the forced expression of specific transcription factors in somatic cells to produce induced pluripotent stem cells (iPSCs) has been long understood to involve a genome wide change in the chromatin environment from a largely repressive environment, non-conducive to wide-spread gene expression to a largely...

May 31, 2012 | Technology

From Developmental Cell
By Stuart P. Atkinson

Protocols for the reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) and the differentiation of pluripotent cells such as iPSCs and embryonic stem cells (ESCs) have taken great strides forward in recent times, increasing the efficiency and the quality of the desired cell product. However, the isolation of...

May 31, 2012 | Pluripotent Stem Cells

From Stem Cells 
By Stuart P. Atkinson

Heterogeneity of stem cells and their progeny has been rightly identified as being a major problem in taking stem cell therapies toward the clinic. Many important studies have attempted to address this problem with the ultimate aim of devising strategies to segregate interesting or potentially useful cell types. A example of this was...

May 20, 2012 | Cancer Stem Cells

'Radiation-induced Reprogramming of Breast Cancer Cells’

From Stem Cells 
Commentary by Carla B. Mellough

In solid cancer tumors, such as those found in breast cancer and glioma, the cancer stem cell (CSC) component represents only a small number of cells within the tumor - yet these cells are the most highly tumorigenic, being able to completely regenerate the...

May 20, 2012 | Pluripotent Stem Cells

From Stem Cells
By Stuart P. Atkinson

Amongst the factors that are know to maintain pluripotent cell types, factors in the FGF pathway are perhaps the most important, as they have been implicated in cell survival, proliferation, pluripotency, and lineage determination during differentiation (Eisellova et al, Lanner and Rossant, Levenstein et al, Vallier...

May 20, 2012 | Pluripotent Stem Cells

From Stem Cells
By Stuart P. Atkinson

Protocols for the production of hepatocytes and insulin-secreting pancreatic beta cells from human embryonic stem cells (hESCs) for treatment of disease and injury, begins with the production of definitive endoderm (DE), but while factors such as Activin A, which activates SMAD2/3, FGF, WNT and BMP (Arnold and Robertson, and Tam and...

May 18, 2012 | Neural Stem Cells

‘Implantation site and lesion topology determine efficacy of a human neural stem cell line in a rat model of chronic stroke’

From Stem Cells
Commentary by Carla B. Mellough

Stroke remains one of the leading causes of mortality and adult disability in developed nations1-3. For the survivors of stroke, the resulting disability is often persistent in nature...

March 30, 2012 | Pluripotent Stem Cells

From Stem Cells
By Stuart P. Atkinson

Multiple studies in the last few years have attempted the production of induced pluripotent stem cells (iPSCs) with a reduced set of reprogramming factors (from OCT4, SOX2, KLF4, MYC or OCT4, SOX2, LIN28 and NANOG) in order that the process becomes streamlined in the hope that this may reduce potential mutation load in the resultant...

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