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Brief reviews of recently published articles, organized by stem cell type.

March 30, 2012 | Pluripotent Stem Cells

From Stem Cells
By Stuart P. Atkinson

Recent studies in the field of induced pluripotent stem cells (iPSCs) through karyotypic (Taapken et al) and meta-analysis of gene expression data (Mayshar et al) have revealed aneuploidy, and also copy number analysis has detected large-scale sub-chromosomal aberrations (Laurent­­ et al and Martins-Taylor...

March 30, 2012 | Cancer Stem Cells

From Stem Cells
By Stuart P. Atkinson

Several recent studies (Ben-Porath et al, Somervaille et al and Wong et al) have identified ESC-like gene expression patterns in a variety of malignant tumors suggesting a molecular relationship between aggressive cancers and pluripotency. However, the molecular determinants of such a link have yet to be...

March 26, 2012 |

The University of Michigan's first human embryonic stem cell line will be placed on the U.S. National Institutes of Health's registry, making the cells available for federally funded research. The university is among just a handful of U.S. universities creating human embryonic stem cell lines. There are only 147 stem cell lines currently available on the registry.

The line, known as UM4...

March 26, 2012 | Pluripotent Stem Cells

The University of Michigan's first human embryonic stem cell line will be placed on the U.S. National Institutes of Health's registry, making the cells available for federally funded research. The university is among just a handful of U.S. universities creating human embryonic stem cell lines. There are only 147 stem cell lines currently available on the registry.

The line, known as UM4...

March 26, 2012 | Cord Blood Stem Cells

A new stem cell study may offer hope for patients suffering from one of the most common causes of childhood deafness.

Sensorineural hearing loss (SNHL) occurs when there is damage to the cochlea or the nerve pathways from the inner ear to the brain. The American Speech-Language Hearing Association says the causes of SNHL can range from genetics and head trauma to drugs, illnesses and...

March 7, 2012 | Pluripotent Stem Cells

The attainment of pluripotency during development has been linked to genome-wide epigenetic changes, such as DNA methylation and histone modifications, and also to the expression of key genes, such as Oct4 and Nanog (Chambers et al, Mitsui et al, Nichols et al and Reik). However, details on how such epigenetic changes affect key pluripotency-associated gene...

March 7, 2012 | Pluripotent Stem Cells

From PNAS
By Stuart P. Atkinson

The mammalian embryo requires properly controlled extrinsic signalling for normal development. Autocrine and paracrine signals are also important in blastocyst-derived embryonic stem cell (ESC) self-renewal (Bendall et al), growth (Mittal and Voldman) and differentiation (Kunath et al and Peerani et al). ...

March 7, 2012 | Pluripotent Stem Cells

From Nature
By Stuart P. Atkinson

Alzheimer’s disease has been associated with certain molecular events, such as the presence of amyloid-β containing plaques (Citron et al and Scheuner et al), neurofibrillary tangles of hyperphosphorylated Tau (MAPT), a microtubule-associated protein (Ballatore et al and Arriagada et al), the co-...

February 14, 2012 |

From Nature
By Stuart P. Atkinson

While metastatic tumour growth is the major cause of cancer mortality, this process is very inefficient for many cancers (Kouros-Mehr et al and Nguyen et al) and suggests that a barrier to implantation and growth exists to these few initiatory cancer cells mediated by the distant tissues in which they attempt to colonize...

February 14, 2012 | Cancer Stem Cells

From Nature
By Stuart P. Atkinson

While metastatic tumour growth is the major cause of cancer mortality, this process is very inefficient for many cancers (Kouros-Mehr et al and Nguyen et al) and suggests that a barrier to implantation and growth exists to these few initiatory cancer cells mediated by the distant tissues in which they attempt to colonize...

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