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Brief reviews of recently published articles, organized by stem cell type.

January 4, 2012 | Pluripotent Stem Cells

From Stem Cells
By Stuart P. Atkinson

In mouse, Pten plays a negative role in the self-renewal of embryonic and adult cell types (Stiles et al, Korkaya et al and Groszer et al) through negative regulation of PI3K/Akt signalling and while studies have shown the importance of PI3K/Akt signalling in embryonic stem cells (ESCs) (Ding et al and...

December 13, 2011 | Pluripotent Stem Cells

From Stem Cells
By Stuart P. Atkinson

The ability to monitor the homogeneity of pluripotent cell cultures and their differentiated derivatives is potentially useful if such cells are to be made applicable to cellular therapy. Another use for such monitoring systems is in the generation of pure induced pluripotent stem cultures (iPSCs) containing only fully reprogrammed...

December 13, 2011 | Direct Reprogramming

From Cell Stem Cell
By Stuart P. Atkinson

Direct conversion of one somatic cell to another somatic cell type, completely bypassing the pluripotent stage through the forced expression of lineage specific transcription factors has emerged as a large “splinter group” of research, taking many lessons from induced pluripotent stem cell (iPSC) technology. The direct generation...

December 13, 2011 | Pluripotent Stem Cells

From Stem Cells
By Stuart P. Atkinson

Induced pluripotent stem cell (iPSC) technology not only has the capability to produce patient-specific but also disease-specific pluripotent cells. In monogenic diseases, there lies the potential for gene modification allowing differentiation of therapeutically relevant “corrected” cells, as has been demonstrated in mouse iPSCs...

December 13, 2011 | Pluripotent Stem Cells

From Cell
By Stuart P. Atkinson

Although multiple studies over the last 5-10 years have begun to unravel the complex network which underlies the pluripotent state of embryonic stem cells (ESCs), bringing together transcription factors, small RNA species, chromatin and DNA methylation events, the specific molecular determinants of the pluripotent state are yet to be fully...

November 18, 2011 | Direct Reprogramming

From PNAS
By Carla Mellough

It is just 5 years since Takahashi and Yamanaka demonstrated that both embryonic and adult mouse somatic cells could be reprogrammed back to a pluripotent state, creating induced pluripotent stem cells (iPSCs). In the short time since this achievement the equivalent has been demonstrated across multiple human somatic cell types, which has...

November 10, 2011 | Pluripotent Stem Cells

From the October Edition of Stem Cells
By Stuart P. Atkinson

A brief report in the October edition of Stem Cells from the laboratory of Steven L. Stice at the University of Georgia, Athens, Georgia, USA describes the ability of pig induced pluripotent stem cells (piPSCs) to be transmitted through the germline and studies the effect of piPSC incorporation on offspring...

November 10, 2011 | Epiblast Stem Cells

From the October Edition of Stem Cells
By Stuart P. Atkinson

Epiblast stem cells (EpiSCs) are derived from postimplantation mouse embryos from embryonic day (E) 5.5 to E7.5 (Brons et al and Tesar et al) and appear to share more characteristics with human embryonic stem cells (hESCs) than with mouse ESCs (mESCs) (Greber et al). EpiSCs are...

November 10, 2011 | Pluripotent Stem Cells

From Nature
By Stuart P. Atkinson

When induced pluripotent stem cell (iPSC) technology broke onto the scene in 2007, the attainment of a practical and ethical source of patient specific pluripotent stem cells seemed to be within our grasp. The use of somatic cell nuclear transfer (SCNT) for the derivation of human embryonic stem cells (hESCs) was all but relegated to the...

November 10, 2011 | Mammary Stem Cells

From the October Edition of Stem Cells
By Stuart P. Atkinson

The E-twenty six transcription factor, Elf5, has been previously identified as an important regulator of mammary alveolar development (Oakes et al and Choi et al). Elf5 is not expressed in the stem cell-enriched compartment of the mammary gland, but is expressed in both luminal progenitors and...

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