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What’s the Stem Cells Buzz this Week? - ACE2 Deficiency Exacerbates Diabetic Defects, Role of Coiled‐coil Mbd3 Domain, OCT4 in Human Cancer, and 3D Organoids as Pre‐Clinical Models

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

What’s the Stem Cells Buzz this Week? - UCB for Ischemic Stroke, Wound Healing with UCB, Scar Reduction by OSKM, and Using Fat to Fight Disease!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

TAP1: The Key to Immune Evasion by Breast Cancer Stem Cells?

Researchers demonstrate that epigenetic silencing of TAP genes in breast cancer stem cells play a crucial role in immune evasion mechanisms

Quality-Quantity Control Culture Boosts the Wound Healing Ability of Diabetic EPCs

A new report describes how a novel culture system boosts the regenerative properties of diabetic endothelial progenitor cells and improves wound healing

Robots grow mini-organs from human stem cells

An automated system that uses robots has been designed to rapidly produce human mini-organs derived from stem cells. Researchers at the University of Washington School of Medicine in Seattle developed the new system. 

The advance promises to greatly expand the use of mini-organs in basic research and drug discovery, according to Benjamin Freedman, Ph.D., assistant professor of medicine, Division of Nephrology, at the UW School of Medicine, who led the research effort.

Researchers operate lab-grown heart cells by remote control

Researchers at University of California San Diego School of Medicine and their collaborators have developed a technique that allows them to speed up or slow down human heart cells growing in a dish on command —  simply by shining a light on them and varying its intensity. The cells are grown on a material called graphene, which converts light into electricity, providing a more realistic environment than standard plastic or glass laboratory dishes.

FDA seeks permanent injunctions against two stem cell clinics

The U.S. Food and Drug Administration (FDA) filed complaints in federal court on May 9 seeking permanent injunctions to stop two stem cell clinics from marketing stem cell products without FDA approval and for significant deviations from current good manufacturing practice requirements.

What’s the Stem Cells Buzz this Week? – Pericyte-mediated Cardiovascular Healing, MSC-Derived Microvesicles, Allogeneic Stem Cell Therapy for RDEB, and MSC-aided Islet Transplantation!

 

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond! 

Boosting the effects of vitamin D to tackle diabetes

More than 27 million people in the United States are living with type 2 diabetes, according to the Centers for Disease Control and Prevention. As the population ages and a growing percentage of people become overweight or obese, that number is expected to increase.

Molecule that supports blood cell production under dietary stress is identified

The production of blood cells is regulated by so-called hematopoietic stem cells (HSCs), which reside in bone marrow. Under certain stress conditions, such as aging or inflammation, the HSCs’ self-renewal capacity — a key property of stem cells — decreases. 

Now, a team of researchers led by Yuko Tadokoro, Ph.D., and Atsushi Hirao from Kanazawa University have studied the role played by a molecule called Spred1 in the homeostasis (equilibrated self-renewal) of HSCs. Their main finding is that Spred1 safeguards HSC homeostasis in mice subjected to a high-fat diet.

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