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Calorie Restriction Promotes Intestinal Regeneration by Reserve Intestinal Stem Cells

A new study identifies mTORC1 activity in reserve intestinal stem cells mediates epithelial regeneration in calorie restricted mice

Single injection treats hemophilia B for life, in proof-of-concept study

For most people with hemophilia B, whose bodies can’t properly form blood clots, constant injections to replenish their clotting factors are a way of life. But now, Salk researchers have demonstrated in mice that hemophilia B can be treated for life with one single injection containing disease-free liver cells that can produce their missing clotting factor.

Fasting boosts stem cells’ regenerative capacity

As people age, their intestinal stem cells begin to lose their ability to regenerate. These stem cells are the source for all new intestinal cells, so this decline can make it more difficult to recover from gastrointestinal infections or other conditions that affect the intestine.

This age-related loss of stem cell function can be reversed by a 24-hour fast, according to a new study from Massachusetts Institute of Technology (MIT) biologists. The researchers found that fasting dramatically improves stem cells’ ability to regenerate, in both aged and young mice.

Stem Cells Might Provide Breakthrough In Treating Severe Blistering Disease, RDEB

Scientists might be close to a breakthrough in finding a treatment for a severe and devastating skin blistering disease. In a study recently published in STEM CELLS Translational Medicine (SCTM), the team details how they used a certain type of stem cells to significantly relieve the symptoms of recessive dystrophic epidermolysis bullosa (RDEB) in mice.

Cancer cells thrive in stiff tissue, according to new study

A recent study shows that stiffer breast tissue creates an environment more prone to cancer by enabling the disease to interfere with the surrounding healthy cells.

Scientists studying tumor growth and metastasis at the University of Notre Dame fabricated a human tissue model to examine how cancer cells interact with connective tissue in the breast. The model allowed the team to control the stiffness of the tissue, mimicking both healthy and cancerous breast tissue structures. They found manipulation of fat cells to be stiffness-dependent.

Liver fix thyself: How some liver cells switch identities to build missing plumbing

By studying a rare liver disease called Alagille syndrome, scientists from Cincinnati Children's and the University of California San Francisco (UCSF) have discovered the mechanism behind an unusual form of tissue regeneration that may someday reduce the need for expensive and difficult-to-obtain organ transplants.

The team's findings, published in Nature, show that when disease or injury causes a shortage in one critical type of liver cell, the organ can instruct another type of liver cell to change identities to provide replacement supplies.

What’s the Stem Cells Buzz this Week? - Inter‐species MSC Incompatibility, Promoting Hippocampal Neurogenesis, HIF‐1α Stability and Chondrogenesis, and p70S6 Kinase-1 in MSCs!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

The Absence of Adult Human Hippocampal Neurogenesis Demonstrated in New Study

New research suggests a lack of neurogenesis in the dentate gyrus of the human adult hippocampus, a finding in disagreement with multiple recent studies

Enhancing the Clinical Potential of Umbilical Cord Blood on Hematopoietic Recovery

A study highlights an efficient means to expand hematopoietic stem/progenitor cells in non-enriched umbilical cord blood thereby boosting clinical potential

Research into Stem Cell-Based Therapies for ARDS Earns Anna Krasnodembskaya the 2017 STEM CELLS Young Investigator Award

Anna D. Krasnodembskaya, Ph.D., has been named STEM CELLS’ Young Investigator of 2017 for her investigations into stem cell-based therapies for acute respiratory distress syndrome (ARDS).

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