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New iPSC-model for Common Cause of Blindness Demonstrates Enormous Potential

A new study employs patient samples to develop a new induced pluripotent stem cell model of the dry form of age-related macular degeneration, a common cause of blindness

CRISPR/Cas9 Embryo Gene-Editing Reveals Species-specific OCT4 Function

A new study employs CRISPR/Cas9 gene-editing to uncover differing developmental roles for the OCT4 pluripotency gene in human and mouse early embryos

Researchers engineer complex TCR immunotherapy that may target relapsing leukemia

Researchers at Fred Hutchinson Cancer Research Center and the University of Washington have developed a novel way to genetically engineer T cells that may be effective for treating and preventing leukemia relapse.

Subset of stem cells identified as source for all cells in blood, immune systems

Researchers at Fred Hutchinson Cancer Research Center have identified a specific subset of adult blood stem cells that is exclusively responsible for repopulating the entire blood and immune system after a transplant.

The discovery, published Nov. 1 in Science Translational Medicine, has the potential to revolutionize blood stem cell transplantation as well as the delivery and targeting of cell and gene therapies that use healthy versions of the self-renewing stem cells to replace ones that are diseased.

What’s the Stem Cells Buzz this Week? - Hematopoietic Regulation and Regeneration, Restoration of Dysfunctional Endothelial Progenitor Cells, and the Production of Mature Heart Muscle!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Stem cells conduct cartilage regeneration but are not directly involved

Therapy with mesenchymal stem cells, the so-called progenitor cells of connective tissue, holds great promise for the regeneration of cartilage tissue. But how stem cell therapy contributes to the healing of damaged connective tissue has been unclear. Debate has centered on whether the injected cells promote regeneration or stimulate the body's own cells to proliferate.

A new strategy has now enabled researchers from the Department of Biomedical Sciences at the University of Veterinary Medicine (Vetmeduni), Vienna, to solve the question.

Discovery of stem cells that help geckos regrow tail could lead to spinal cord treatment

A University of Guelph researcher is the first to discover the type of stem cell that is behind the gecko's ability to re-grow its tail, a finding that has implications for spinal cord treatment in humans.

Many lizards can detach a portion of their tail to avoid a predator and then regenerate a new one. Unlike mammals, the lizard tail includes a spinal cord. Matthew Vickaryous, Ph.D., found that the spinal cord of the tail contained a large number of stem cells and proteins known to support stem cell growth.

Application of New Human ESC Reporter Cell Line Enhances Differentiation of Important Retinal Cells

Researchers have improved the differentiation of RGCs by creating a new and improved reporter human ESC line generated via CRISPR/Cas9 genome editing 

Cell Volume modulates Mesenchymal Stem Cell Fate

Researchers studying microenvironmental influences on cell mechanics highlight a link between changes in cell volume and the differentiation potential of mesenchymal stem cells

 

What’s the Stem Cells Buzz this Week? – Inflammatory Cycling in MSCs, Slimming-down MSCs with Vesicles, Boosting Bone and Cartilage Regeneration, and Trialing Autologous Cord Blood!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

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