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Stem cell-derived intestine model mimics innate immune responses

A stem cell-derived in vitro model displays key small intestine characteristics including innate immune responses, according to a study by Ying Chen, Ph.D., and David Kaplan, Ph.D., from Tufts University (Boston, Massachusetts) and colleagues.

What’s the Stem Cells Buzz this Week? - Treating Ischemic Retinopathies, Anti-tumor Immune Cells, MSC Rejection Trial, and Huntington's Disease!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Surprising roles for muscle in tissue regeneration, study finds

A team of researchers has illuminated an important role for different subtypes of muscle cells in orchestrating the process of tissue regeneration. In a paper published in the November 22 issue of Nature, they reveal that a subtype of muscle fibers in flatworms is required for triggering the activity of genes that initiate the regeneration program. Notably, in the absence of these muscles, regeneration fails to proceed.

Another type of muscle, they report, is required for giving regenerated tissue the proper pattern – for example, forming one head instead of two.

Scientists find key to regenerating blood vessels

A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) identifies a signaling pathway that is essential for angiogenesis, the growth of new blood vessels from pre-existing vessels. The findings may improve current strategies to improve blood flow in ischemic tissue, such as that found in atherosclerosis and peripheral vascular disease associated with diabetes.

Deletion of a stem cell factor promotes traumatic brain injury recovery in mice

Researchers report the unexpected finding that selectively deleting a stem cell transcription factor in adult mice promotes recovery after traumatic brain injury (TBI).

The Centers for Disease Control and Prevention defines TBI as a bump, blow or jolt to the head that disrupts normal brain function, ranging from mild (brief changes in mental status) to severe (marked by an extended period of unconsciousness or memory loss). In humans, most TBIs are mild and are called concussions.

HLF-gene controls the generation of long-term immune system

A research group at Lund University in Sweden has found that when the HLF (hepatic leukemia factor) gene – which is expressed in immature blood cells – does not shut down on time, we are unable to develop a functional long-term immune system. This could be a very early stage of leukemia.

What’s the Stem Cells Buzz this Week? - Lung Patterning, Injury-induced Transdifferentiation, MSC Pilot Study, and Universal Mutation Correction!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

Paving the way for testing experimental drugs in more realistic environments, scientists at the National Institute of Standards and Technology (NIST) have discovered how to make tiny colonies of cells grow in useful new ways inside petri dishes.

Key to unlock blocked differentiation in microRNA-deficient embryonic stem cells

The more than 200 different types of human cells have the same DNA but express different ensembles of genes. Each cell type was derived from embryonic stem cells, which are called pluripotent stem cells because they can differentiate to all those different cell fates.

One very active area of biology is cells that mimic these fountainhead embryonic stem cells, cells that are called induced pluripotent stem cells, or iPSCs. With genetic and biochemical tricks, researchers can reverse a differentiated cell — such as a skin fibroblast — into a pluripotent state.

This is why testicular cancer is so responsive to chemo

Cornell University researchers have taken a major step toward answering a key question in cancer research: Why is testicular cancer so responsive to chemotherapy, even after it metastasizes?

Professional cyclist Lance Armstrong, for example, had testicular cancer that spread to his lung and brain, yet he made a full recovery after conventional chemotherapy.


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