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2D to 3D Switch Boosts the Regenerative Potential of Cord Blood

A new study demonstrates how a three-dimensional culture substrate can help to maintain the number of primitive stem cells present during the expansion of human cord blood samples

Cell therapy could improve brain function for Alzheimer's disease

Like a great orchestra, your brain relies on the perfect coordination of many elements to function properly. And if one of those elements is out of sync, it affects the entire ensemble. In Alzheimer's disease, for instance, damage to specific neurons can alter brainwave rhythms and cause a loss of cognitive functions.

Mending broken hearts with cardiomyocyte molds

Whether caused by an undetected birth defect or by a heart attack (myocardial infarction), when a heart sustains damage it can be difficult to repair.

If heart muscle cells — cardiomyocytes — could be repaired by cells taken from one’s own body, the patient's recovery improves. But manufacturing heart cells requires an exacting process tailored specifically to an individual.

Chimeric cells show potential for helping Duchenne MS patients

Cells made by fusing a normal human muscle cell with a muscle cell from a person with Duchenne muscular dystrophy — a rare but fatal form of muscular dystrophy — were able to significantly improve muscle function when implanted into the muscles of a mouse model of the disease.

Clearing clumps of protein in aging neural stem cells boosts their activity

Young, resting neural stem cells in the brains of mice store large clumps of proteins in specialized cellular trash compartments known as lysosomes, researchers at the Stanford University School of Medicine have found.

As the cells age, they become less proficient at disposing of these protein aggregates and their ability to respond readily to “make new neurons” signals wanes. Restoring the ability of the lysosomes to function normally rejuvenates the cells’ ability to activate, the researchers found.

Zeb2-NAT lncRNA: Breaking Down Age-associated Reprogramming Barriers

A new study identifies a long non-coding RNA as an important barrier impeding the reprogramming of cells derived from old patients

Osteoblast Differentiation Study Recommends Choosing your Stem Cell Wisely!

A new study suggests that DNA methylation analysis of select gene promoters can identify the optimal pluripotent stem cell for bone repair strategies

Researchers pinpoint gene behind autism, other neurodevelopmental disorders

A study led by researchers at McMaster University has pinpointed a gene that is responsible for neurodevelopmental disorders, including autism.

They found alterations of the gene called “thousand and one amino-acid kinase 2,” known as TAOK2, plays a direct role in these disorders. This is the first comprehensive study that supports previous research suggesting the involvement of this gene.

The study was published in Molecular Psychiatry.

Regenerative process of brain’s neural stem cells unveiled

Waseda University researchers recently elucidated the regenerative processes by neural stem cells using a stab injury model in the optic tectum, a less studied area of the brain, of adult zebrafish. This study has brought them a step closer to shedding light on how an injured, human central nervous system (CNS) could be restored.

New Cell Treatment Shows Promise in Curing a Deadly Side Effect of Stem Cell Transplants

A new study appearing in STEM CELLS Translational Medicine demonstrates the promise of a type of cell found in the placenta in helping those suffering from painful and life-threatening severe acute graft-versus-host disease (GvHD). GvHD occurs in up to 70 percent of patients who have undergone a stem cell transplant to treat a disease such as leukemia, using cells other than their own. GvHD develops because the donor's immune cells attack the patient's normal cells.

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