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Donor stem cells used to treat spinal cord injury in mice

A new study in mice, conducted by researchers at the University of California, Irvine, details a potential therapeutic strategy that uses stem cells to promote recovery of motor activity after spinal cord injury.

The transplantation of neural stem cells could help promote repair of an injured spinal cord, but the interaction between donor cells and the resident cells that are part of the body's immune response to injury is not well understood.

What’s the Stem Cells Buzz this Week? – Hepatic Differentiation, Repairing CNS Damage, Enhancing HSC Engraftment, and SSCs for Osteoporosis Treatment!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Cancer Stem Cell Study Uncovers Potential Means to Improve Disease Treatment

A new study into colorectal cancer suggests that targeting FBXW7 may increase the sensitivity of cancer stem cells to commonly employed chemotherapeutics

CAMKK1 Overexpression: A New and Effective Strategy to Improve Cardiac Repair?

A new study suggests that CAMKK1 overexpression in mesenchymal stem cells can potentiate cardiac repair via the modulation of secreted paracrine acting factors

Electric New Study Guides NSC Migration to Enhance Neurological Disease Therapies

A new study demonstrates the guidance of neural stem cell migration in the mammalian brain employing applied electric fields

Severe aplastic anemia and hypoplastic MDS focus of new clinical trial

The first subject has been transplanted in an investigator-initiated study of Cordin™ for patients with severe aplastic anemia (AA) or hypoplastic myelodysplastic syndrome (MDS) who have no available matched donor. 

 The study is being conducted by Richard W. Childs, M.D., clinical director of the National Heart, Lung and Blood Institute's (NHLBI) Division of Intramural Research in the National Institutes of Health (NIH) and Assistant United States Surgeon General.

ViraCyte Announces Positive Phase 2 Trial Results

ViraCyte LLC, a clinical stage biopharmaceutical company developing cellular immunotherapies for severe infections, reported positive data from a Phase 2 clinical trial evaluating its T-cell immunotherapy product, Viralym-M. The results were reported by ViraCyte lead investigators at Baylor College of Medicine in the Journal of Clinical Oncology.  

What’s the Stem Cells Buzz this Week? – Modeling Glaucoma, Accelerating Fracture Healing, Treating Lung Disease, and a Lung Disease Workshop Report!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Discovery shows vitamin C regulates stem cell function and suppresses leukemia

A new study from the Children’s Medical Center Research Institute (CRI) at the University of Texas Southwestern has found that stem cells take up unusually high levels of vitamin C, which then regulates their function and suppresses the development of leukemia.

“We have known for a while that people with lower levels of ascorbate (vitamin C) are at increased cancer risk, but we haven’t fully understood why. Our research provides part of the explanation, at least for the blood-forming system,” said Sean Morrison, Ph.D., CRI’s director.

Mouse model of human immune system inadequate for stem cell studies

A type of mouse widely used to assess how the human immune system responds to transplanted stem cells does not reflect what is likely to occur in patients, according to a study by researchers at the Stanford University School of Medicine. The researchers urge further optimization of this animal model before making decisions about whether and when to begin wide-scale stem cell transplants in humans.

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