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Generating functioning cardiac cells from stem cells in single step

The process by which embryonic stem cells develop into heart cells is a complex process involving the precisely timed activation of several molecular pathways and at least 200 genes. Now, Salk Institute scientists have found a simpler way to go from stem cells to heart cells that involves turning off a single gene.

The work, which appeared early online in Genes & Development on December 21, offers scientists a streamlined method to arrive at functioning heart cells (cardiomyocytes) for both research and regenerative therapies.

What’s the Stem Cells Buzz this Week? - BM‐MSC-EVs ameliorate GVHD, MS-QC of hESCs, Adult Lung Repair, hMSC Metabolic Changes after Transplants!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

New Study Highlights a Key Role for Adipocytes in Acute Myeloid Leukemia

Researchers studying hematopoietic failure in acute myeloid leukemia highlight an unexpected role for adipocytes and in doing so discover a new treatment strategy

Bone Marrow MSCs Defeat ASCs in an Osteogenic Face-Off

A study compares the in vivo osteogenic potential of mesenchymal stem cells and adipose-derived stem cells in the hope of creating efficient bone repair strategies

What’s the Stem Cells Buzz this Week? - Cancer Immunotherapy, Cellular Conspiracy of ALS, Vav1-null HSPCs, and Leukemic BM Niche Adaptation!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Researchers track dynamics behind why stem cells respond differently to injury and aging

A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP), La Jolla, California, describes the biology behind why muscle stem cells respond differently to aging or injury. The findings have important implications for therapeutic strategies to regenerate skeletal muscle in response to the normal wear and tear of aging, or in cases of injury or muscle diseases such as muscular dystrophy.

Study prompts new ideas on cancers’ origins

Rapidly dividing, yet aberrant stem cells are a major source of cancer. But a new study suggests that mature cells also play a key role in initiating cancer — a finding that could upend the way scientists think about the origins of the disease.

Therapy that modifies patients’ own blood cells to fight advanced cancers being tested

Scientists have taken a step forward in efforts to harness patients’ own white blood cells to fight deadly cancers. A pilot study, funded by Montefiore Einstein Center for Cancer Care, in partnership with New York Blood Center (NYBC), has demonstrated that white blood cells can be removed, genetically modified and reinserted into cancer patients.

This holds potential to fight cancers that standard therapy has failed to treat. The next step is to duplicate this finding in multiple patients. 

New Model Highlights a Mature Cell of Origin for Melanoma

A new study suggests that dedifferentiated mature melanocytes represent the cell of origin for melanoma, and not stem cells as previously thought

Exploring how Insulin Affects Neural Stem Cells: An New role for Cdk4!

A new study indicates that insulin controls adult neural stem cell proliferation and differentiation via the activities of cyclin-dependent kinase 4

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