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In vitro Generation of hPSC-derived Functional Skeletal Muscle Tissue

For the first time, researchers describe the formation of entirely hPSC-derived 3D muscle tissues that survive, vascularize, and maintain function following transplantation

Researchers study nanoscaffold for heart cells

Biophysicists from Moscow Institute of Physics and Technology (MIPT) have studied the structure of a nanofibrous scaffold, as well as its interaction with rat cardiac cells. The study, which is part of the research into heart tissue regeneration, revealed that cardiomyocytes (heart muscle cells) envelop nanofibers as they grow, while fibroblasts (connective tissue cells) tend to spread out on fibers forming several focal adhesion sites.

Scientists identify genes that enable adult cells to divide and multiply

Some organisms have a remarkable capacity for regenerating tissue. If a fish or salamander suffers heart damage, for instance, their cells are able to divide and successfully repair the injured organ. Imagine if you could do the same.

In the embryo, human heart cells can divide and multiply, allowing the heart to grow and develop. The problem is that, right after birth, cardiomyocytes (heart muscle cells) lose their ability to divide. The same is true for many other human cells, including those of the brain, spinal cord and pancreas.

Mutation explains why some are more vulnerable to viral brain infection

For previously healthy children, brain infections are rare. But about one out of every 10,000 people who are exposed to common viruses like herpes simplex or influenza will develop a potentially deadly disease, encephalitis.

Findings pave way for regenerative cell therapies in type 1 diabetes patients

Scientists from the Diabetes Research Institute at the University of Miami Miller School of Medicine (Miami) have confirmed the existence of progenitor cells within the human pancreas that can be stimulated to develop into glucose-responsive beta cells. These findings open the door to developing regenerative cell therapies for those living with type 1 diabetes, addressing a major challenge that stands in the way of discovering a biological cure for the disease. 

Stem-cell study points to new approach to Alzheimer's disease

Improving the trafficking of cellular proteins in brain cells holds possibilities for new treatments and even prevention for Alzheimer's disease, results of a new study suggest. Researchers found that a compound that enhances the shuttling of proteins within cells reduced the production of forerunners of two proteins implicated in brain cell death.

What’s the Stem Cells Buzz this Week? - 3D CB-HSPC Culture, PDLSCs and RGC Survival, Anti‐angiogenic MACS, and How Sleep and Epigenetics affect Neurogenesis!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

A Role for CD133 in Stem Cell-Mediated Kidney Repair

A new study describes a putative role of the stem cell-associated pentaspan-trans-membrane glycoprotein CD133 in coordinating stem cell-mediated repair of kidney damage

Correlating Genome Topology and Gene Regulation during Reprogramming

Using an efficient and synchronous reprogramming system, researchers describe the dynamic alterations to genome topology, chromatin states, and gene expression

New HSC Rejuvenation Strategy May Improve Bone Marrow Transplantation

Researchers discover that treatment with microvesicles from young MSCs can rejuvenate aged HSCs and potentially improve bone marrow transplantation outcomes


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