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Hitting the bullseye on cancer stem cells

Researchers have identified a unique feature of cancer stem cells that can be exploited to kill the deadly cells thought to be the reason that cancer comes back after therapy. Understanding this feature will be useful for delivering more targeted cancer therapeutics to the right patients.

Study Pinpoints Best Stage of Stem Cell Differentiation for Use in Treating Parkinson’s Disease

DURHAM, NC - Studies indicate that replacing damaged brain cells with those derived from human embryonic stem cells might lead to an effective treatment for Parkinson’s disease. But what has not been determined is the optimal stage during differentiation of the stem cells that the transplantation should take place to gain the best results.

What’s the Stem Cells Buzz this Week? - Regenerating the Diabetic Heart, Tissue Repair with Stem Cell-EVs, ESC-Derived Dopaminergic Neurons, and Trialing ADRCs for Breast Cancer-Related Lymphedema!

A roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond brought to you by the Stem Cells Portal!

Lab-grown human colons could change study of GI disease

Scientists used human pluripotent stem cells to generate human embryonic colons in a laboratory that function much like natural human tissues when transplanted into mice. The study is believed to be the first time human colon organoids have been successfully tissue engineered in this manner, according to researchers at Cincinnati Children’s Hospital Medical Center who led the project.

Grape-based compounds kill colon cancer stem cells in mice

Compounds from grapes may kill colon cancer stem cells both in a petri dish and in mice, according to research from Penn State University.

Resveratrol — part of a group of compounds found in grape skins and seeds — could also eventually lead to treatments to help prevent colon cancer, said Jairam K.P. Vanamala, associate professor of food sciences, Penn State. Colorectal cancer is the second leading cause of cancer-related deaths in the United States, according to the American Cancer Society.

The Safe, Effective, and Non-Invasive Production of Induced Pluripotent Stem Cells from Down Syndrome Patients

A new means to generate Down Syndrome specific iPSCs may lead to enhanced cell-based treatments for associated pathologies and a deeper understanding of disease development

Adipose Tissue and Immunomodulation: It’s not what you do, it’s where you do it!

New research indicates that adipogenic differentiation of mesenchymal stem cells alters their immunomodulatory capabilities, with consequences for inflammatory disorders

Bioengineered human livers mimic natural development

An international team of researchers bioengineering human liver tissues uncovered previously unknown networks of genetic-molecular crosstalk that control the organ's developmental processes – greatly advancing efforts to generate healthy and usable human liver tissue from human pluripotent stem cells.

The scientists report online in Nature on June 14 that their bioengineered human liver tissues still need additional rounds of molecular fine tuning before they can be tested in clinical trials.

What’s the Stem Cells Buzz this Week? – TEC and hPSCs, Hemodynamic Vascular Cell induction, Ex vivo-generated Erythrocytes, and MSC Treatment for Felines!

A roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond brought to you by the Stem Cells Portal

Chip captures individual cells in minuscule gels

Researchers at the University of Twente’s Mira Research Institute have developed a chip that can capture and hold individual cells in the exact center of a minuscule hydrogel droplet. Their novel method keeps cells alive for multiple weeks, which makes it easier to study them.

This makes it possible to, for example, test the action of new drugs and improve stem cell therapies with unparalleled control. Details of this research were published in Small.

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