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Discovery may advance neural stem cell treatments for brain disorders

New research from Sanford Burnham Prebys Medical Discovery Institute (SBP) is among the first to describe how an mRNA modification impacts the life of neural stem cells (NSCs). The study, published in Nature Neuroscience, reveals a novel gene regulatory system that may advance stem cell therapies and gene-targeting treatments for neurological diseases such as Alzheimer's disease, Parkinson's disease and mental health disorders that affect cognitive abilities.

What’s the Stem Cells Buzz this Week? - Differing Stem Cell Interests, Fanconi anemia MSCs, Pro‐angiogenic Hematopoietic Cells, and a Study under Discussion!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Exploring ASC Treatment for Diabetes-related Vascular Damage

New research suggests that NOTCH2 expression in adipose stem cells promotes their ability to treat the vascular damage associated with diabetes

CRISPR/Cas9-mediated in vivo Epigenetic Remodeling: A New Means to Treat Disease?

Researchers describe the application of CRISPR/Cas9-mediated epigenetic remodeling to treat kidney injury, diabetes, and muscular dystrophy in vivo

Biomaterial Mobilizes Host Stem Cells to Promote Kidney Regeneration

A new study establishes that the injection of a collagen-based biomaterial can mobilize endogenous stem cells to promote kidney regeneration in a mouse model

Researchers identify gene responsible for mesenchymal stem cells’ stem-ness

Many doctors, researchers and patients are eager to take advantage of the promise of stem cell therapies to heal damaged tissues and replace dysfunctional cells. Hundreds of ongoing clinical trials are currently delivering these therapies to patients worldwide.

Study could explain link between high-cholesterol diet and colon cancer

New research from the University of California Los Angeles (UCLA) could help explain the link between a high-cholesterol diet and an elevated risk for colon cancer. Scientists from the David Geffen School of Medicine have discovered that boosting cholesterol levels in mice spurred intestinal stem cells to divide more quickly, enabling tumors to form 100 times faster.

Their study identifies a molecular pathway that could serve as a new drug target for colon cancer treatment.

What’s the Stem Cells Buzz this Week? - Spinal Cord Injury Repair, Cancer Stem Cells, NSC Store‐operated Channels, and Reprogramming with Wnt!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Universal CRISPR-Cas9 Mutation Correction Strategy in Human Pluripotent Stem Cells

Researchers describe how a new “universal” strategy for CRISPR-Cas9-mediated gene correction in patient derived stem cells may represent a promising therapeutic option

Promoting Mesenchymal Stem Cell Function with Survivin

A new study describes the role of the inhibitor-of-apoptosis protein family member Survivin in the survival and function of mesenchymal stem cells


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