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Another Step towards the Fully Synthetic Culture of Human Pluripotent Stem Cells

A new study takes the field further towards the industrial-scale culture and safe and cost-effective clinical application of human pluripotent stem cells

ASC and OEC Co-transplantation: A new and Improved Strategy for Spinal Cord Injury Repair?

Combined treatment of spinal cord injury with adipose-derived stem cells and olfactory ensheathing cells leads to high levels of repair in a rat model

‘Golden Bear’ tells how stem cell treatment eased debilitating back pain

Pro golfer Jack Nicklaus is the latest celebrity athlete to reveal that he has undergone stem cell treatment. In an interview with CNN, the six-time Masters Tournament champion told how he traveled to Germany in February 2016 to be treated for debilitating back pain by stem cell pioneer Dr. Eckhard Alt, M.D., Ph.D.

Experimental arthritis drug prevents stem cell transplant complication

An investigational drug in clinical trials for rheumatoid arthritis prevents a common, life-threatening side effect of stem cell transplants, new research from Washington University School of Medicine in St. Louis shows. Studying mice, the researchers found the drug prevented what’s known as graft-versus-host disease, a debilitating, sometimes lethal condition that develops when transplanted stem cells attack the body’s own organs or tissues.

New light shed on how bone marrow niches keep stem cells thriving

Hematopoietic stem cells (HSCs) are a class of stem cells located in bone marrow. HSCs give rise to every type of blood cell —from the red blood cells that carry oxygen to the white blood cells of the immune system. Bone marrow provides a niche that both houses and regulates HSCs to ensure proper formation of blood cells. However, the precise mechanisms that maintain the HSC niche are not fully understood.

Chinese researchers develop new drug to inhibit cancer stem cells

Researchers say they have developed a new drug that inhibited the growth and spread of cancer stem cells when tested on mice.

The drug, called WYC-209, killed or inhibited the proliferation of stem cells of melanoma and lung, ovarian and breast cancers, according to the study that was published in Nature Communications on April 11. The researchers also found that the molecular targeted synthetic drug prevented metastasis of lung cancer in 87.5 percent of cases.

Neurons derived from super-obese people respond differently to appetite hormones

U.S. scientists have successfully generated hypothalamic-like neurons from human induced pluripotent stem cells (hiPSCs) taken from the blood and skin cells of super-obese individuals and people with a normal body weight. The researchers found that the brain cells derived from the super obese were more likely to dysregulate hormones related to feeding behavior and hunger, as well as obesity-related genes and metabolic pathways.

Endangered salamander offers clues on healing spinal cord injury

One of the most vexing problems with spinal cord injuries is that the human body does not rebuild nerves once they have been damaged. Other animals, on the other hand, seem to have no problem repairing broken neurons.

A new study takes a comparative approach to pinpoint what happens differently in humans versus other animals to explain why they can successfully regenerate neurons while we instead form scar tissue. By learning from the similarities and differences, researchers hope to find new leads in the treatment of spinal cord injury.

Study showing frog embryos can fully regrow eyes after injury could someday benefit humans

A University of Nevada, Las Vegas (UNLV) scientist and her team have found that frog embryos can fully regrow their eyes after injuries, a breakthrough that may lead one day to the ability to orchestrate tissue regeneration in humans.

The study by UNLV scientist Kelly Tseng, Ph.D., was recently published in the journal Experimental Eye Research.

What’s the Stem Cells Buzz this Week? - Stem Cell Radiation Risk, Olfactory Epithelium Progenitor and Stem Cells, MSCs and Heart Disease, and, EpCAM and Colorectal Cancer!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

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