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IFATS 09 - Top Abstracts

First-In-Man Experience of Adipose-Derived Stem Cell Transplantation in the Treatment of Patients with an Acute ST-Elevation Myocardial Infarction (APOLLO Trial - Cytori).

H.J. Duckers*; Patrick Serruys**

* Erasmus Medical Centre, Erasmus University, Rotterdam, the Netherlands
** Department of Interventional Cardiology, Erasmus Medical Centre, Erasmus University, Rotterdam, the Netherlands

Introduction:
A number of pilot trials as well as two larger randomized trials have shown a significant benefit of treatment with bone marrow mononuclear cells in acute myocardial infarction (AMI). Autologous adipose-derived regenerative cells (ADRCs) can be obtained from subcutaneous adipose tissue in sufficient amount for therapy and require no cell culture step before use. While similar to bone marrow derived adult stem cells in differentiation potential, the usual abundance of adipose tissue in human patients and the higher frequency of adult stem cells per unit mass (including mesenchymal stem cells and EPCs) allows fast isolation of an efficacious number of cells without having to culture expand them. Preparation of therapeutic doses of ADRCs involves no cell culture and can be achieved in less than two hours from the time of donor tissue acquisition. This allows for treatment during the same procedure as the harvest of the adipose tissue and can thus be appended to the primary percutaneous coronary interventional treatment (PCI) of an acute myocardial infarction.

IFATS 09 - Meeting Summary

Report from the 6th Annual Meeting of the International Federation of Adipose Therapeutics and Science (IFATS)

Toulouse, France October 24-26, 2008

IFATS, the world’s only interdisciplinary fat tissue society, recently held their 2008 annual meeting in Toulouse, France. This conference was the largest in the organization’s history, bringing together 200 scientists from over 13 different countries, to share knowledge and ideas, and discuss applications and issues regarding the use of stem cells derived from fat to regenerate and repair tissues. Investigators in basic and translational science and therapy attended 5 plenary sessions, designed to cover the most recent advances in stem cells and regenerative medicine, in addition to 35 oral abstract presentations and 85 poster presentations.

Dr. George Daley's Lab

Dailey
The Daley Laboratory
Children's Hospital Boston
Boston, Massachusetts

Dr. Brigid Hogan’s Lab

Hogan
Department of Cell Biology
Duke University Medical Center
Durham, NC

Dr. Michael Rudnicki's Lab

rudnicki
Ottawa Health Research Institute
Ottawa ON, CANADA

Dr. James Thomson's Lab

Thomson
Department of Anatomy
Genome Center of Wisconsin

Madison, WI

Dr. Fiona Watt's Lab

Watt
Cancer Research UK Cambridge Research Institute

Li Ka Shing Centre
Cambridge, UK

Dr. Ariff Bongso's Lab

Bongso
Department of Obstetrics and Gynaecology,
National University of Singapore

Kent Ridge, Singapore

Dr. Christine Mummery's Lab

Mummery
Chair, Department of Anatomy and Embryology
Leiden University Medical Center

The Netherlands

Dr. Barbara Knowles and Dr. Davor Solter's Lab

Knowles
Institute of Medical Biology

Mammalian Development Laboratory
Singapore

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