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Potential Stem Cell Therapy for HIV Reported

Potential Stem Cell Therapy for HIV Reported

From Nature Biotech

An advance online article from Nature Biotechnology reports the creation of genetically modified human hematopoietic stem/progenitor cells which when injected and engrafted in mice confer some resistance to HIV.   Specifically, Holt et al disrupted CCR5, the major HIV-1 co-receptor using engineered zinc-finger nucleases (ZFNs) and compared to control mice, the mice which received such cells showed significantly lower HIV-1 levels.

Potential Stem Cell Therapy for HIV Reported

Potential Stem Cell Therapy for HIV Reported

From Nature Biotech

An advance online article from Nature Biotechnology reports the creation of genetically modified human hematopoietic stem/progenitor cells which when injected and engrafted in mice confer some resistance to HIV.   Specifically, Holt et al disrupted CCR5, the major HIV-1 co-receptor using engineered zinc-finger nucleases (ZFNs) and compared to control mice, the mice which received such cells showed significantly lower HIV-1 levels.

Human iPSC Generated from Peripheral Blood Cells

Human iPSC Generated from Peripheral Blood Cells

From Cell Stem Cell and Stem Cells and Development

Articles in the new edition of Cell Stem Cell and an online advance report from Stem Cells and Development report the production of human induced pluripotent stem cells (iPSCs) from peripheral blood samples, suggesting another potentially easier target cell for reprogramming, rather than cells from skin biopsies which require invasive collection techniques and long culture periods before use.   Navigate to the papers from Seki et al, Loh et al, Staerk et al and Kunisato et al by clicking on the hyperlinks.   Also see here for a preview of this work by Shinya Yamanaka.

 

Human iPSC Generated from Peripheral Blood Cells

Human iPSC Generated from Peripheral Blood Cells

From Cell Stem Cell and Stem Cells and Development

Articles in the new edition of Cell Stem Cell and an online advance report from Stem Cells and Development report the production of human induced pluripotent stem cells (iPSCs) from peripheral blood samples, suggesting another potentially easier target cell for reprogramming, rather than cells from skin biopsies which require invasive collection techniques and long culture periods before use.   Navigate to the papers from Seki et al, Loh et al, Staerk et al and Kunisato et al by clicking on the hyperlinks.   Also see here for a preview of this work by Shinya Yamanaka.

 

A Step Forward In Understanding Melanoma

A Step Forward In Understanding Melanoma

From Nature and Cell

Two studies, by Roesch et al in Cell and Boiko et al in Nature, have shed more light on the development of this skin cancer, and have also reported two potential biomarkers of a melanoma cancer stem cell, CD271, a stem cell marker, and JARID1B (KDM5B), a lysine 4 histone H3 demethylase.   Identification of these markers may allow for better modeling of this cancer with a view towards better clinical management/treatment.

A Step Forward In Understanding Melanoma

A Step Forward In Understanding Melanoma

From Nature and Cell

Two studies, by Roesch et al in Cell and Boiko et al in Nature, have shed more light on the development of this skin cancer, and have also reported two potential biomarkers of a melanoma cancer stem cell, CD271, a stem cell marker, and JARID1B (KDM5B), a lysine 4 histone H3 demethylase.   Identification of these markers may allow for better modeling of this cancer with a view towards better clinical management/treatment.

Germline stem cells: Public Row Ensues

Germline stem cells: Public Row Ensues

From Nature News

Recent correspondence in Nature has brought into question claims of the pluripotent nature of human adult germline stem cells (haGSCs) generated from human testicular tissue reported in 2008 from the lab of Thomas Skutella.   Read more in the Nature News article and read the correspondence and the authors reply, from Nature.

Germline stem cells: Public Row Ensues

Germline stem cells: Public Row Ensues

From Nature News

Recent correspondence in Nature has brought into question claims of the pluripotent nature of human adult germline stem cells (haGSCs) generated from human testicular tissue reported in 2008 from the lab of Thomas Skutella.   Read more in the Nature News article and read the correspondence and the authors reply, from Nature.

New egg screening technique may boost the success rate of IVF

New egg screening technique may boost the success rate of IVF

From BBC

A new egg screening technique pioneered by Care Fertility and reported at the European Society of Human Reproduction and Embryology (ESHRE) conference in Rome, can predict genetic problems in 90% of cases. Use of this technique could lead to increases in pregnancy rates from IVF.   Read the entire story here.

 

New egg screening technique may boost the success rate of IVF

New egg screening technique may boost the success rate of IVF

From BBC

A new egg screening technique pioneered by Care Fertility and reported at the European Society of Human Reproduction and Embryology (ESHRE) conference in Rome, can predict genetic problems in 90% of cases. Use of this technique could lead to increases in pregnancy rates from IVF.   Read the entire story here.

 

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