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MSC-derived Extracellular Vesicles Battle Inflammation with Inflammation!

New research demonstrates how proinflammatory stimuli can promote the production of extracellular vesicles from MSCs with enhanced immunomodulatory capacity.

What’s the Stem Cells Buzz this Week? - Translating Regenerative Biology, Cord Blood Transplantation, Stem Cell Product Approval, and MSC Osteogenic Stimulation!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Gene therapy using CAR T-cells could provide long-term protection against HIV

Researchers at the University of California, Los Angeles (UCLA) have found a way to engineer blood-forming stem cells to carry chimeric antigen receptor genes to make cells that can detect and destroy HIV-infected cells. These engineered cells not only destroyed the infected cells, they persisted for more than two years — suggesting the potential to create long-term immunity from the virus that causes AIDS.

Growing organs a few ink drops at a time

Printed replacement human body parts might seem like science fiction, but this technology is rapidly becoming a reality with the potential to greatly contribute to regenerative medicine. Before any real applications, "bioprinting" still faces many technical challenges.

What’s the Stem Cells Buzz this Week? - MSC Homeostasis, Transplantable Photoreceptors, CD133 link to Lipid Rafts, and Polycystin‐2 Role in Autophagy!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Podocyte Comparison Highlights the Potential of Pluripotent Stem Cell-derived Kidney Organoids

New comparative study highlights the utility of human pluripotent stem cell-derived organoids in studies of kidney development and kidney disease

Cord Blood Trial for Cerebral Palsy in Children Highlights Dosing Effect

A new trial in children with cerebral palsy suggests that autologous cord blood infusions may have the potential to improve motor function

New grant funds study of immune cell activity in stem cell transplantation

A team of University of California Davis investigators has been awarded a $1.2 million grant to examine a common virus and its effects on immune system function after stem cell transplantation.

The National Heart, Lung, and Blood Institute grant, $300,000 per year for four years, will fund a multi-disciplinary team of researchers led by William Murphy, Ph.D., professor and vice chair for research in the Departments of Dermatology and Internal Medicine.

(Re)-acquiring the potential to become everything

Scientists have identified a specific population of pluripotent embryonic stem cells that can reprogram to totipotent-like cells in culture. Moreover, the scientists, from Helmholtz Zentrum München and Ludwig-Maximilians-Universität München (LMU), have identified bottlenecks and drivers of this reprogramming.

Skeletal muscle created from stem cells

Scientists have developed a new strategy to efficiently isolate, mature and transplant skeletal muscle cells created from human pluripotent stem cells (hPSCs), which can produce all cell types of the body. The findings are a major step toward developing a stem cell replacement therapy for muscle diseases, including Duchenne Muscular Dystrophy, which affects approximately one in 5,000 boys in the United States and is the most common fatal childhood genetic disease.


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