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Plant substance inhibits cancer stem cells

The plant Ambrosia arborescens grows wild in much of South America and is traditionally used as a medicinal plant. Researchers at the Faculty of Science at Lund University, in collaboration with colleagues in La Paz, Bolivia, have isolated the substance damsin from the plant and studied its effect on cancer stem cells in three different breast cancer cell lines. 

They have also done similar studies with ambrosin, a substance similar to damsin, but produced by chemical means. The results show that both have an effect on cancer stem cells.

What’s the Stem Cells Buzz this Week? - Endometrial Regenerative Cells, Paralogous Bone Marrow Niche Model, ONS Cell Conduits, and Transplanted Fetal Liver Progenitor Cell Fate!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Investigating Adipose-derived Cells as a Treatment for Multiple Sclerosis

A new study investigates the great potential of adipose-derived cells as a novel treatment strategy for the autoimmune neurodegenerative disease Multiple Sclerosis

Inhibiting Age-related Bone Loss by Eliminating Senescent Cells

The clearance of senescent cells in old mice reverses age-related bone loss and may represent an exciting new anti-aging therapy in human patients

Enhanced Bone Fracture Healing with Engineered Mesenchymal Stem Cells

The overexpression of basic fibroblast growth factor boosts bone fracture healing capacity of mesenchymal stem cells via the secretion of paracrine-acting factors

Faulty cell signaling derails brain development

As the embryonic brain develops an incredibly complex cascade of cellular events occur, starting with progenitors — the originating cells that generate neurons and spur proper cortex development. If this cascade malfunctions — if one tiny protein doesn't do its job — then the brain can develop abnormally.

Study finds immune system critical to regeneration

The answer to regenerative medicine's most compelling question —why some organisms can regenerate major body parts such as hearts and limbs while others, such as humans, cannot — may lie with the body's innate immune system, according to a new study of heart regeneration in the axolotl, or Mexican salamander, an organism that takes the prize as nature's champion of regeneration.

Production of key diabetes cells can be improved

In the future people with diabetes might benefit from getting insulin-regulating beta cells transplanted into their body because their own beta cells are destroyed or less functional. However, according to new stem cell research at the University of Copenhagen, the current way of producing beta cells from stem cells has significant shortfalls. The beta cells produced have some features resembling alpha cells.

'Labyrinth' chip could help monitor aggressive cancer stem cells

Inspired by the Labyrinth of Greek mythology, a new chip etched with fluid channels sends blood samples through a hydrodynamic maze to separate out rare circulating cancer cells into a relatively clean stream for analysis. It is already in use in a breast cancer clinical trial.

Mechanism behind age-associated bone loss described

Researchers have detailed an underlying mechanism that leads to a major health problem for older people, osteoporosis. When this mechanism malfunctions, progenitor cells stop creating bone-producing cells and instead create fat cells.

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