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Is an Extracellular Matrix Component the Key to Adult Cardiac Regeneration?

A new study finds that the extracellular matrix component Agrin promotes adult cardiac regeneration in a mouse model of heart disease

FDA grants orphan drug status to Cellect's Apograft for acute GVHD and chronic GVHD

The U.S. Food and Drug Administration (FDA) has granted orphan drug designation for Cellect Biotechnology Ltd.'s ApoGraft™ for the prevention of acute and chronic graft versus host disease(GvHD) in transplant patients. Cellect is a developer of stem cells selection technology.

What’s the Stem Cells Buzz this Week? - Kidney Generation with hPSCs, hPSC Hematopoietic Differentiation, LeX-SSEA1 in NSCs, and Allogeneic ASCs for Heart Disease!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

New model for hard-to-study form of blindness paves way for future research

Macular degeneration is the leading cause of vision loss in older adults, but scientists have long struggled to study and replicate key elements of the disease in the lab. A study published in the Proceedings of the National Academy of Sciences is the first to demonstrate hallmarks of macular degeneration in a new human stem cell model developed by researchers at the University of Rochester Medical Center. 

Zika virus kills brain cancer stem cells

While Zika virus causes devastating damage to the brains of developing fetuses, it one day may be an effective treatment for glioblastoma, a deadly form of brain cancer. New research from Washington University School of Medicine in St. Louis and the University of California San Diego School of Medicine shows that the virus kills brain cancer stem cells, the kind of cells most resistant to standard treatments.

Phase 2 clinical trial begins for stem cell therapy to treat aging frailty

Longeveron LLC, a regenerative medicine company developing cellular therapies, has treated its first patient in a Phase 2b clinical trial evaluating the safety and efficacy of its human allogeneic mesenchymal stem cells (LMSCs) in patients with aging frailty syndrome. Aging frailty is a common geriatric medical condition that is serious and life-threatening, and for which there are currently no U.S. Food and Drug Administration-approved therapeutics available.

Human skin cells transformed directly into motor neurons

Scientists working to develop new treatments for neurodegenerative diseases have been stymied by the inability to grow human motor neurons in the lab. Motor neurons drive muscle contractions, and their damage underlies devastating diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy, both of which ultimately lead to paralysis and early death.

In new research, scientists at Washington University School of Medicine in St. Louis, Missouri, have converted skin cells from healthy adults directly into motor neurons without going through a stem cell state.

What’s the Stem Cells Buzz this Week? - Reviewing Stem Cell Bioprinting, Cardiovascular Regeneration with MSCs, Hair Follicle Stem Cell Regulation, and Sepsis and Septic Shock Treatment!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Primitive Neural Stem Cells: It’s Quiescent at the Top!

Researchers describe the existence of a quiescent primitive neural stem cell type that can proliferate and replenish definitive neural stem cells when required

Stem Cell Therapy for Parkinson's Disease - Which Cell is Best?

A comparative study indicates that immature dopaminergic neurons derived from hPSCs represent the ideal cell type for replacement therapy in Parkinson’s Disease

 

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