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Stem cell-derived retinal organoid imaging offers real-time insights into origins of blinding eye diseases

A multidisciplinary team of researchers from the University of Southern California (USC) Roski Eye Institute, Children's Hospital Los Angeles (CHLA) and USC Viterbi School of Engineering, used stem cell-derived retinal organoids and enhanced imaging technologies to assess an important retinal development and disease model.

Stanford announces new Center for Definitive and Curative Medicine

The Stanford Center for Definitive and Curative Medicine, a joint initiative of the Stanford University School of Medicine, Stanford Health Care and Stanford Children’s Health, opened recently to provide the organizational and physical infrastructure to support investigator-initiated clinical translational studies on stem cell and gene therapy. The center will work to turn discoveries into stem cell and gene therapies to aid the millions of people who have genetic diseases.

iPSC-derived Vascular Cells Go with the Flow!

A new study shows that exposure to blood flow hemodynamics can improve the maturation of vascular cells derived from induced pluripotent stem cells

Successful First in Man Trial for MSC-based Cartilage Repair

Researchers report on a successful cartilage repair trial using a simple strategy involving mesenchymal stem cell and patient-derived chondrocytes

Bone Repair via Ultrasound-mediated Gene Delivery to Endogenous Stem Cells

A new study indicates that ultrasound-mediated gene delivery of BMP-6 to endogenous mesenchymal stem cells represents an exciting new bone repair strategy

What’s the Stem Cells Buzz this Week? – pNSC Brain Repair, Pluripotent stem cell‐derived Osteoblasts, Chemokine Treatment for ISD, and Adverse Events in Adipose-Derived Cell Therapy!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Using pig model to study chronic diseases may help minimize drug failure rate

Scientists may be able to minimize the failure rate of drugs for diseases linked to high-calorie diets, such as colon cancer and type 2 diabetes, if they test treatments using a pig model, according to an international team of researchers.

'Nano-in-micro' stem cell delivery could rescue blood flow after injury

When blood flow is reduced or cut to tissues, cells are deprived of oxygen and nutrients, which can lead to cell death if blood flow isn’t efficiently restored. Stem cells are promising treatments, but they do not tend to stay at the site or survive long enough to heal the damage.

In a study appearing in the current ACS Central Science, researchers combined micro and nano approaches to improve stem cell therapies and outcomes after ischemia, or inadequate blood supply.

$2.8 million grant supports stem cell research for neurological repair

A $2.8 million grant from the National Institutes of Health (NIH) will help researchers at Rosalind Franklin University of Medicine and Science, Chicago, Illinois, study how to replace neurons lost through stroke, traumatic brain and spinal injury and brain diseases including Alzheimer's.

Innate reaction of hematopoietic stem cells to severe infections

Researchers at the University of Zurich have shown for the first time that hematopoietic stem cells detect infectious agents themselves and begin to divide without signals from growth factors. This direct production of defensive cells damages hematopoiesis in the long term, however, which could lead to malignant hematopoietic stem cell diseases at advanced age.

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