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Researchers create first stem cells using CRISPR genome activation

In a scientific first, researchers at the Gladstone Institutes turned skin cells from mice into stem cells by activating a specific gene in the cells using CRISPR technology. The innovative approach offers a potentially simpler technique to produce the valuable cell type and provides important insights into the cellular reprogramming process.

Dr. Philippe Lysy’s Search in New Sources for Insulin-Producing Cells Earns Him the 2017 SCTM Young Investigator Award

STEM CELLS Translational Medicine (SCTM) named Philippe Lysy, M.D., Ph.D., the STEM CELLS Translational Medicine’s Young Investigator of 2017 for his exploration of new sources of cells capable of conversion into insulin-secretors.

What’s the Stem Cells Buzz this Week? - Breast Cancer Stem Cells, Cornea-derived MSCs, Study under Discussion, and hiPSC Models of Retinitis Pigmentosa!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Novel hypothesis on why animals diversified on Earth

Can tumors teach us about animal evolution on Earth? Researchers believe so and now present a novel hypothesis of why animal diversity increased dramatically on Earth about half a billion years ago.

A biological innovation may have been key.

A transdisciplinary and international team, from Lund University in Sweden and University of Southern Denmark, presents their findings in Nature and Ecology.

Hedgehog signaling proteins keep cancer stem cells alive

Colon cancer is the third most common cancer and fourth most common cause of death worldwide. Colon tumors consist of different types of cells, which play different roles in the growth of the tumor. The development and spread of cancer is thought to be caused by a subpopulation of cells that possess stem cell characteristics, including the capacity for self-renewal, differentiation and therapy resistance. These “cancer stem cells” are also thought to be the source of cancer recurrence following initial treatment success.

How metal scaffolds enhance the bone healing process

In cooperation with colleagues from the Wyss Institute at Harvard, researchers from the Julius Wolff Institute of the Charité – Universitätsmedizin Berlin, the Berlin-Brandenburg Center for Regenerative Therapies (BCRT) and Charité’s Center for Musculoskeletal Surgery have shown how mechanically optimized constructs known as titanium-mesh scaffolds help optimize bone regeneration. The induction of bone regeneration is of crucial significance when treating large bone defects.

‘Decorated’ stem cells could offer targeted heart repair

Although cardiac stem cell therapy is a promising treatment for heart attack patients, directing the cells to the site of an injury – and getting them to stay there – remains challenging. In a new pilot study using an animal model, North Carolina State University researcher Ke Cheng, Ph.D., and his team show that “decorating” cardiac stem cells with platelet nanovesicles can increase the stem cells’ ability to find and remain at the site of heart attack injury and enhance their effectiveness in treatment.

What’s the Stem Cells Buzz this Week? – A Novel DPPA4 Cofactor, Stem Cell Protection, Stem Cell Myocardial Repair, and the Fate of MSCs!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Surfen Towards Glycan-mediated Control of Embryonic Stem Cells

Researchers describe how modulating glycan-mediated growth factor association and signaling can maintain mESCs in a pluripotent state

Reversing Signs of Aging via Splicing with Reversalogues

A new study suggests that resveratrol-like compounds that can target multiple mRNA splicing factors may reverse the signs of cellular aging

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