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The Best Papers from Our 2016 Young Investigators

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The STEM CELLS Young Investigator Award honors a young scientist who is principal author of a significant research paper published in STEM CELLS. The 11th annual award recipient is Gunes Uzer, PhD. Here, we feature Dr. Uzer’s paper, chosen by a panel of judges composed of our Senior Editors. “STEM CELLS is delighted to honor Dr. Uzer for his important research into molecular mechanisms by which stem and progenitor cells respond to their environments,” said Jan Nolta, PhD, editor-in-chief of SC and director of the University of California Davis Institute for Regenerative Cures. “This paper from Dr. Uzer and team deciphers the signals by which the nucleus and cytoskeleton are coupled in response to mechanotransduction. This type of research is critical to formulating methods to use stem cells in therapy, as well as to deepen our comprehension of basic cell biology. 

Dr. Uzer’s paper, “Cell Mechanosensitivity to Extremely Low-Magnitude Signals Is Enabled by a LINCed Nucleus,” is featured below, along with the top finalists for the 2016 award. The STEM CELLS Editors support the efforts of emerging researchers and encourage the development of these young investigators who are making significant impacts in this field, thus fostering the future of their clinical applications.

Find out more about the winner of the 2016 STEM CELLS Young Investigator Award.


Cell Mechanosensitivity to Extremely Low-Magnitude Signals Is Enabled by a LINCed Nucleus
Gunes Uzer, William R. Thompson, Buer Sen, Zhihui Xie, Sherwin S. Yen, Sean Miller, Guniz Bas, Maya Styner, Clinton T. Rubin, Stefan Judex, Keith Burridge, Janet Rubin

HucMSC-Exosome Mediated-Wnt4 Signaling Is Required for Cutaneous Wound Healing
Bin Zhang, Mei Wang, Aihua Gong, Xu Zhang, Xiaodan Wu, Yanhua Zhu, Hui Shi, Lijun Wu, Wei Zhu, Hui Qian, Wenrong Xu

Interleukin-17A-Induced Human Mesenchymal Stem Cells Are Superior Modulators of Immunological Function
Kisha Nandini Sivanathan, Darling M. Rojas-Canales, Christopher M. Hope, Ravi Krishnan, Robert P. Carroll, Stan Gronthos, Shane T. Grey, Patrick T. Coates

Transcriptome Dynamics of Developing Photoreceptors in Three-Dimensional Retina Cultures Recapitulates Temporal Sequence of Human Cone and Rod Differentiation Revealing Cell Surface Markers and Gene Networks
Rossukon Kaewkhaw, Koray Dogan Kaya, Matthew Brooks, Kohei Homma, Jizhong Zou, Vijender Chaitankar, Mahendra Rao, Anand Swaroop

Molecular Mechanisms Mediating Retinal Reactive Gliosis Following Bone Marrow Mesenchymal Stem Cell Transplantation
Alessia Tassoni, Alex Gutteridge, Amanda C. Barber, Andrew Osborne, Keith R. Martin

microRNA-103/107 Family Regulates Multiple Epithelial Stem Cell Characteristics
Han Peng, Jong Kook Park, Julia Katsnelson, Nihal Kaplan, Wending Yang, Spiro Getsios, Robert M. Lavker

Universal Cardiac Induction of Human Pluripotent Stem Cells in Two and Three-Dimensional Formats: Implications for In Vitro Maturation
Boris Greber, Miao Zhang, Jan Sebastian Schulte, Alexander Heinick, Ilaria Piccini, Jyoti Rao, Roberto Quaranta, Dagmar Zeuschner, Daniela Malan, Kee-Pyo Kim, Albrecht Röpke, Philipp Sasse, Marcos Araúzo-Bravo, Guiscard Seebohm, Hans Schöler, Larissa Fabritz, Paulus Kirchhof, Frank Ulrich Müller