You are here

Discovery of Cardiac Progenitor Cell Proliferators

Small molecule activators of cardiac progenitor cell proliferation may form part of regenerative therapies for the treatment of myocardial infarction. Now, researchers led by Jane McPheat (AstraZeneca, Gothenburg, Sweden) used a  phenotypic screen to identify retinoic acid receptor agonists as potent and specific “proliferators” of induced pluripotent stem cell‐derived cardiac progenitor cells. Drowley et al. hope to follow up this research, published in STEM CELLS Translational Medicine, by investigating how this mechanism translates in vivo to activate endogenous cardiac progenitor cells and if enhancing the proliferation of these progenitor cells can enhance cardiac repair.