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Neural Stem Cells from Neuroepithelial Stem Cells

A recent study from the labs of Philipp Koch (University of Heidelberg/Medical Faculty Mannheim) and Oliver Brüstle (University of Bonn, Germany) explored whether stable neuroepithelial stem (NESCs) derived from human pluripotent stem cells can give rise to neural stem cells with radial glia‐like properties. Ostermann et al. now report on the in vitro transition of human NESCs into radial glia‐like NSCs, define the developmental relationship between in vitro propagated human NSC systems, and provide a matrix for the relationship between pluripotent stem cell‐derived populations and their native counterparts in the brain. For all the exciting details, see STEM CELLS now!