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What’s the Stem Cells Buzz this Week? – p107 and Adipogenic Fate, Heart Failure Therapeutics, Creating PSC-derived Neural Cells, and MMP-controlled AMSC Differentiation!



A roundup of some the recent stories in the ever-changing world of stem cells and regenerative medicine

Adipogenic Lineage Differentiation Requires transcriptional corepressor p107

A new study from the laboratory of Anthony Scimè (York University, Toronto, Canada) has demonstrated, for the first time, that the cell cycle transcriptional corepressor p107, or Retinoblastoma-like 1, determines adipocyte lineage fates for non-committed progenitors via the control of a metabolic checkpoint. This new Stem Cells paper establishes metabolism for lineage commitment and may have further roles in metabolic switches in conditions such as cancer. Interesting stuff!

Biological Therapeutics for Heart Failure

A new review article from the lab of Ioannis Karakikes (Stanford University School of Medicine, Stanford, CA, USA) aspires to bring you up to date with “recent advances in cell- and gene-based therapies in the context of cardiovascular disease, emphasizing the most advanced therapies”. Heart failure as a consequence of cardiovascular disease remains a huge clinical problem, so head over to Stem Cells now to find out the current state of affairs and all the “emerging technologies that hold promise to revolutionize the biological therapies for cardiovascular diseases”.

Creating PSC-derived Neural Cells: Simple and Animal Free!

A new study from the laboratory of Slaven Erceg (CIPF, Valencia, Spain) describes a new platform for the simple, efficient, and animal-free neural conversion of human pluripotent stem cells (hPSCs). Their new protocol also does away with embryoid bodies and instead employs adherent culture conditions and human extracellular matrix components. The team hopes that this new protocol will enhance the clinical applicability of hPSC-derived cells; see the details over at Stem Cells Translational Medicine.

MMP-mediated Regulation of Porcine AMSC Endothelial Differentiation

Three-dimensional extracellular matrix barriers remodeling during cell differentiation; however, we currently do not understand the controlling molecular mechanisms. The lab of Devendra K. Agrawal (Creighton University School of Medicine, Omaha, Nebraska, USA) sought to understand this in the context of porcine adipose-derived mesenchymal stem cell (AMSC) differentiation to endothelial cells (ECs). In their new Stem Cells Translational Medicine study, Almalki et al demonstrate, for the first time, that silencing specific matrix metalloproteinases inhibits the cleavage of vascular endothelial growth factor receptor type 2 (VEGFR2) and thereby stimulate the differentiation of AMSCs to ECs. Can we apply this information to boost the re-endothelialization of coronary arteries?

So that’s a wrap for this week! Please let us know your views on all the stories we have covered here on the Stem Cells Buzz, and please let us know if we have missed anything interesting! Happy reading!