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What’s the Stem Cells Buzz this Week? - 3D CB-HSPC Culture, PDLSCs and RGC Survival, Anti‐angiogenic MACS, and How Sleep and Epigenetics affect Neurogenesis!



The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Effects of 3D-ECM Constructs on CB-HSPC

Classical 2D culturing techniques employed to amplify cord blood-derived hematopoietic stem/progenitor cell (HSPC) number lead to the loss of the most primitive and most therapeutically relevant stem cell content. However, new research from the labs of Graça Almeida-Porada and Shay Soker (Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC, USA) now demonstrates that switching from 2D culture conditions to 3D liver cell-coated extracellular-matrix constructs leads to the increased maintenance of primitive HSPCs, thereby increasing the therapeutic potential of cord blood samples. See this new article by Mokhtari et al. at STEM CELLS now!

PDLSCs Promote RGC Survival and Axon Regeneration

Previous research from Chi Pui Pang and Mingzhi Zhang (Joint Shantou International Eye Center of Shantou University/Chinese University of Hong Kong, China) discovered the enormous potential for human periodontal ligament-derived stem cells (PDLSCs) in retinal cell replacement. Now, Cen et al. report that PDLSCs can reduce retinal ganglion cell (RGC) degeneration induced by optic nerve injury and promote axon regeneration in vitro and in vivo. The authors hope that the newly described neuroprotective role of PDLSCs may find use in treating human patients in the near future. See STEM CELLS now for all the details.

MACs turn Anti‐angiogenic in Diabetes

Researchers from the lab of Reinhold J. Medina (Queen's University Belfast, UK) recently investigated how diabetes may affect treatment of diabetic-related ischemia with myeloid angiogenic cells (MACs). Chambers et al. discovered that MACs isolated from peripheral blood are less reparative and more inflammatory in the diabetic environment, making them less useful in tissue repair and regeneration. However, the authors hope that targeting IL1β, a key mediator of MACs anti-angiogenic nature in response to diabetes, may provide a means to restore their desired pro-reparative effect. For that and more, head over to STEM CELLS now!

Sleep, Epigenetics, and Adult Neurogenesis

A new review in STEM CELLS from the group of Masanori Sakaguchi (University of Tsukuba, Japan) details our current understanding of the influence of both sleep and epigenetics on adult neurogenesis in the dentate gyrus (DG) of the hippocampus. Akers et al. suggest that further insight into the interactions between sleep-related neural processes and epigenetic mechanisms may lead to novel strategies to prevent or treat a wide range of disorders. For what sounds like an enthralling read, head over to STEM CELLS now!

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!