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What’s the Stem Cells Buzz this Week? - Breast Cancer Stem Cells, Cornea-derived MSCs, Study under Discussion, and hiPSC Models of Retinitis Pigmentosa!

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The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Immune Evasion by Breast CSCs

Breast cancer stem cells (CSCs) can evade immune detection, so promoting tumor initiation and progression. To discover just how CSCs achieve this feat, researchers from the lab of Paola Marcato (Dalhousie University, Halifax, Canada) examined CSCs derived from a murine mammary tumor in immunocompetent and immunocompromised mice. Overall, Sultan et al. suggest that immune evasion mechanisms in breast CSCs are marker specific and the epigenetic silencing of the Transporter associated with Antigen Processing 1 (TAP1) gene contributes to enhanced survival under immune pressure. For all the details, see STEM CELLS now!

Corneal MSCs Modulate Macrophages

New research from the labs of Peiman Hematti and Ali R. Djalilian (University of Illinois at Chicago, USA) recently sought to test the ability of corneal-derived mesenchymal stem cells (cMSCs) to influence macrophages, as a potential part of an immunomodulatory therapeutic approach. Eslani et al. established that cMSCs therapeutically modulated the inflammatory and angiogenic functions of macrophages and went on to highlight the role of cMSC-secreted pigment epithelium-derived factor (PEDF) in this modulation. See STEM CELLS now for all the exciting details.

Under Discussion: “Bone marrow stem cells do not contribute to endometrial cell lineages in chimeric mouse models”

A recent study (“Bone Marrow Stem Cells Do Not Contribute to Endometrial Cell Lineages in Chimeric Mouse Models”) from James A. Deane (Hudson Institute of Medical Research, Victoria, Australia) has come under discussion with the publication of an article from Deepa Bhartiya (National Institute for Research in Reproductive Health, Mumbai, India) and the reply from the original authors. For a thought-provoking back and forth regarding the possible role of very small embryonic-like stem cells (VSELs) (or not!) in this study, head on over to STEM CELLS.

Reviewing hiPSC Models of Retinitis Pigmentosa

A new article from the lab of Slaven Erceg (Centro de Investigación Príncipe Felipe, Valencia, Spain) provides a review of current human induced pluripotent stem cell (hiPSC)-based retinitis pigmentosa models and highlight the critical achievements and challenges of these cellular models. Furthermore, the team underlines some of the thorny questions that remain unanswered in the quest to treat hereditary retinal dystrophies. See STEM CELLS now for a great read!

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!