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What’s the Stem Cells Buzz this Week? - Endometrial Regenerative Cells, Paralogous Bone Marrow Niche Model, ONS Cell Conduits, and Transplanted Fetal Liver Progenitor Cell Fate!

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The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

ERCs Induce Cardiac Allograft Tolerance

Studies have demonstrated the therapeutic potential of mesenchymal-like endometrial regenerative cells (ERCs) in various disease models, and now, new research from Hao Wang (Tianjin Medical University General Hospital, China) assesses their application in transplant tolerance. Lan et al. discovered that human ERC-based therapy induced allograft tolerance via the activity of stromal cell-derived factor-1 (SDF-1) when investigating mouse cardiac allografts between different strains. Do ERCs hold promise for therapeutic use in future clinical transplantations? See STEM CELLS Translational Medicinenow to find out!

Proposal of a New Dynamic Paralogous Bone Marrow Niche Model

A lack of agreement into the origins of various bone marrow (BM) stem-cell niches, cell identities, and their physiological roles has led Kevin G. Chen and Pamela G. Robey (NIH, Bethesda, Maryland, USA) to propose a new BM niche model. In their new study, the authors propose a new hypothesis of “paralogous” stem cell niches (PSNs); i.e., progressively altered parallel niches within an individual species throughout the lifespan of the organism. Head over to STEM CELLS now to discover what this new model could mean for precision regenerative medicine and pharmaceutical applications based on BM cell resources.

Promoting Peripheral Nerve Repair with an ONS Cell-Conduit

The team of Fergal J. O'Brien (Royal College of Surgeons in Ireland, Dublin, Ireland) recently reported on an exciting new means to promote the repair of peripheral nerve damage. Roche et al. describe the repair of peripheral nerve damage in rats following the transplantation of olfactory derived stem (ONS) cells grown on a collagen and laminin functionalized hyaluronic acid-based nerve guidance conduit (NGC). See STEM CELLS Translational Medicine now to find out more about the strategy with the potential to aid millions of patients each year!

Discovering the Fate of Transplanted Fetal Liver Progenitor Cells

A new study from the labs of Dan Yock Young (National University, Singapore) sought to ascertain the long-term fate of human fetal progenitor liver cells following the transplantation into immune-permissive mice. Irudayaswamy et al. discovered that progenitor cells engrafted and differentiate into functional human hepatocytes, functional endothelial cells, and bile duct cells and also aided in the repair of liver fibrosis, with no sign of unwanted cell growth. Overall, this STEM CELLS study suggests that liver progenitor cells transplanted into injured livers maintain a functional role in repair and regeneration.

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!