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What’s the Stem Cells Buzz this Week? - Exosome Mediated Lung Repair, NSPC Metabolic Regulation, Tenogenic Control by AKT‐mTOR, and Oligodendrocyte Differentiation by AKAP12!

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The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

hAEC Exosome Mediated Lung Repair

Researchers from the laboratory of Rebecca Lim (Hudson Institute of Medical Research, Victoria, Australia) recently sought to explore treatment with human amnion epithelial cell-derived exosomes (hAEC Exo) as a potential treatment for idiopathic pulmonary fibrosis (IPF).  Tan et al. describe how the proteins contained within exosomes polarized and increased macrophage phagocytosis, reduced neutrophil myeloperoxidases, and suppressed T cell proliferation directly, all leading to reduced lung inflammation following bleomycin challenge. For all the details, see in a recent STEM CELLS Translational Medicine.

Nestin‐Cdk5‐Drp1 Axis in Metabolic Regulation of NSPCs

In an attempt to fully understand the mechanisms of neural stem/progenitor cells (NSPCs) stemness regulation, to advance their therapeutic potential, researchers from the lab of Andy Peng Xiang (Sun Yat-Sen University, Guangdong, China) have discovered a new metabolic “axis”. Wang et al. now describe how the Nestin‐Cdk5‐Drp1 axis promotes mitochondrial fission and glycolysis, which is indispensable for NSPC maintenance. For more of the fine print, see STEM CELLS now!

AKT‐mTOR axis regulates MSC Tenogenesis

Stimulating heightened levels of tenogenesis in mesenchymal stem cells (MSCs) may prove an invaluable strategy for the tendon reparative strategies. Now, the research teams of Yi Ting Zhou and Xiao Chen (Zhejiang University, China) reveal that the AKT‐mTOR axis represents an essential mediator of MSC collagen production and tenogenesis, offering a potential therapeutic target for tendon repair strategies. See STEM CELLS now for all the details.

 

AKAP12 in Adult White Matter

The processes that control the differentiation of oligodendrocyte precursor cells (OPCs) to oligodendrocytes in cerebral white matter remain to be fully described. However, a new STEM CELLS study from the labs of Ken Arai and Eng H. Lo (Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School, USA) now hopes to shed a little more light onto the process. Maki et al. demonstrate how oligodendrocyte renewal by OPCs in young‐adult mice requires the function of A‐kinase anchor protein 12 (AKAP12), a scaffolding protein that associates with intracellular molecules such as protein kinase A.

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!