| Dr. Barbara Knowles and Dr. Davor Solter's Lab |
 Institute of Medical Biology Mammalian Development Laboratory Singapore
“Unraveling the molecular complexity that underlies plasticity between the embryonic stem cell/differentiated cell state has become one of the major scientific themes of our time. The transcriptome, the signal transduction mechanisms regulating its stability and translation, and chromatin modifications are inter-related mechanisms that control this change of cell fate. In earlier times we investigated cell surface molecules and extracellular matrix changes accompanying embryonic stem cell differentiation. In recent years we have focused on the oocyte-to-embryo transition, gaining knowledge of the transcriptome and molecular processes that govern activation of the embryonic genome. We now propose to reciprocally study these processes in vivo in mouse oocytes and embryos and in vitro in human and mouse embryonic stem cells.”
Dr. Barbara Knowles
Dr. Davor Solter Barbara Knowles’ Homepage Davor Solter’s Homepage About the Institute of Medical Biology Singapore Stem Cell Bank (SSCB) Singapore Stem Cell Consortium (SSCC) Stem Cell Society Singapore (SCSS)
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