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Adipose Stem Cells

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Enhanced ASC-mediated Cell Therapies via Klotho

A new study highlights the potential importance of the Klotho gene in the enhancement of adipose stem cell-based therapies

Boosting Angiogenesis with Microvesicles and miRNA

Study finds that microvesicles derived from adipose stem cells can induce angiogenesis via the delivery of a specific microRNA

New Storage Strategy Enhances Clinical Use of Adipose Stem Cells

A seaweed-derived product can protect stem cells from cell death and loss of function during storage and transport at ambient temperatures

A Perfect Stem Cell Source to Treat the Damaged Heart?

Researchers assessing the cardiac differentiation potential of several adipose-derived stem cells describe an optimal cell source

IER3 – A New Target in the War against Obesity?

A new study into obesity and the regulation of adipocyte progenitor cell differentiation highlights a key role for microenvironmental factors and the immediate early response 3 (IER3) gene.

Long Term Stem Cell Triumph in the Treatment of Crohn’s Side Effect

Clinical trial finds that injection of adipose-derived stem cells represents a successful therapy in the long term for Crohn’s fistula

Pilot Study of Adipose Stem Cells in the Treatment of Urinary Incontinence

Small scale clinical study demonstrates the potential utility of stem cells derived from adipose tissue for the treatment of female incontinence problems

Stem Cells Straight from the Source Prove Therapeutically Relevant for MS

Adult stem cell therapies usually rely on extraction, purification, expansion and then re-infusion/re-implantation, with each stage entailing their own specific risks and disadvantages. Adipose-derived stem cells (ASCs) are a therapeutically important cell type taken from the stromal vascular fraction (SVF) made up of numerous cell types: vascular smooth muscle cells, fibroblasts, mast cells, macrophages, lymphocytes, endothelial cells, preadipocytes, as well as ASCs (see paper for extensive references).

Age Related Decline in ASC Therapeutic Function in MS Model

 Multiple sclerosis (MS) is a neurodegenerative disease characterized by inflammation and scarring throughout the central nervous system (CNS) which currently has no cure (Jadasz et al).

Increasing the Survival of ASCs to Promote Regeneration

Enhancing In Vivo Survival of Adipose-Derived Stromal Cells Through Bcl-2 Overexpression Using a Minicircle Vector

From Stem Cells Translational Medicine

Survival of therapeutically relevant multipotent stem cells, such as human adipose-derived stromal cells (hASCs), is currently a significant hurdle to stem cell therapy.   This barrier is primarily caused by environmental stresses on transplanted cells by the often refractory cellular environment on the transplant site (Allen et al, Bauer et al and Broughton et al).   This often leads to apoptosis (Zhang et al) and poor engraftment (Wu et al), and therefore it has been postulated that modulating the apoptosis pathway may enhance the therapeutic worth of stem cells.   In a study published in Stem Cells TM, the group of Michael T. Longaker at the Stanford University School of Medicine, USA have studied the overexpression of the Bcl-2 gene, known to imbue survival advantages (Domen and Domen and Weissman), in hASCs and demonstrated an increased level of tissue regeneration which can be translated to a clinical setting (Hyun et al).

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