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Mesenchymal Stem Cells

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Stem Cell Treatment for Back Pain Shows Success

MSC-laden cell injections into lumbar discs mediate a significant reduction in back pain, promoting this minimally invasive stem cell strategy

Engineered MSCs Improve Diabetes Therapy

A pretty “sweet” Stem Cells article has been hitting the news this week.

Moderating Atherosclerosis with Mesenchymal Stem Cells?

Mesenchymal stem cells found to be effective in treating models of atherosclerosis in vitro and in vivo

Improving Organ Function after Injury by Targeting Stem Cells?

Researchers find that a small fraction of perivascular mesenchymal-like stem cells contribute to fibrosis in organs after injury, and that ablation of these cells can improve organ function

Magnetic MSCs Mediate Maximal Mineralization!

Exciting magnetic nanoparticle technology improves mesenchymal stem cell mediated bone repair

Dopamine-mediated Induction of Mesenchymal Progenitor Cell Mobilization for Therapeutic Use

Researchers further our understanding of the indirect means by which the nervous system can modulate stem cell systems, underlining a role for dopamine in the mobilization of mesenchymal progenitor cells

Less Oxygen Better Bone Healing?

Researchers discover that delayed hypoxia treatment can enhance bone healing in a mouse model

Uncovering miRNA-mRNA Interactions in the Bone Marrow

The generation of an miRNA-mRNA interaction map in cells that make up the bone marrow niche allows regulatory pathways for signalling factors to be understood.

Immunomodulatory effects of MSCs to Aid Transplantation?

Alterations in the Cellular Immune Compartment of Patients Treated with Third-Party Mesenchymal Stromal Cells Following Allogeneic Hematopoietic Stem Cell Transplantation

From Stem Cells

Allogeneic hematopoietic stem cell transplantation is often complicated by graft-versus-host disease (GVHD) mediated by the donors immune cells (Ferrara et al) and novel intervention strategies are highly sought after.   Mesenchymal stem cells (MSCs) are known to have immunoregulatory properties and have been applied in clinical trials (Le Blanc et al), although few reports have shed light on the effects of MSCs on the patient's immune system (Dander et al).   Now, in a study published in Stem Cells, researchers from the laboratory of Katarina Le Blanc at the Karolinska University Hospital, Stockholm, Sweden have investigated the alterations in the immune system caused by third-party (i.e. from an unrelated source) MSC treatment to aid in the design of future clinical studies and to establish novel monitoring procedures (Jitschin and Mougiakakos et al).

NPR-A Aids Stem Cell Migration

“Natriuretic Peptide Receptor A Signaling Regulates Stem Cell Recruitment and Angiogenesis: A Model to Study Linkage Between Inflammation and Tumorigenesis”

Natriuretic peptide receptor A (NPRA) is expressed on cells in inflamed or injured tissues and in tumours (Kong et al and Wang et al) and through cGMP-dependent protein kinase (PKG) signalling (Airhart et al and Chen et al), it upregulates genes affecting cell proliferation and inflammation, although a greater level of detail remains to be uncovered. Researchers from the group of Subhra Mohapatra at the University of South Florida, Tampa, Florida, USA have previously shown that NPRA is an early biomarker for human prostate cancer (Wang et al) as well as recently establishing NPRA as a biomarker for melanoma, colon, and pancreatic cancer, and have reasoned that NPRA signaling may promote tumourigenesis by influencing recruitment of immune and progenitor cells, thereby fostering angiogenesis. In their newest study, published in Stem Cells, the group use NPRA-knock out (NPRA-KO) mice as a model and find that that NPRA signaling is indeed linked to angiogenesis partially through progenitor cell recruitment (Mallela et al).

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