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New Muscle Stem Cell Expansion Technique May Boost Muscle Regeneration Strategies

A new soft fibrin culture substrate permits the selective expansion of muscle stem cells from bulk muscle tissue

Magnetic Sorting Promotes Clinical Applicability of Smooth Muscle Progenitor Cells

A new study describing the magnetic sorting of smooth muscle progenitor cells derived from human induced pluripotent stem cells may promote their clinical application

Investigating the Intracellular Regulators of Muscle Stem Cells

A new study describes the importance of the KLF7 transcription factor in the regulation of muscle stem cell activity

Reversing Muscle Stem Cell Aging with pro-IGF-II?

New research finds that a post-translationally processed isoform of IGF-II may be able to promote muscle regeneration in the elderly by modulating the muscle stem cell microenvironment

Lkb1 - Muscling onto the Stem Cell Scene

Researchers identify a protein kinase vitally important to muscle stem cell function.

Can a Simple Laminin Injection Aid Exercise-Associated Muscle Damage?

Supplementation of a simple laminin protein known to enhance muscle stem cell and overall muscle function may allow for an improved regenerative muscular response to exercise.

Improved Gene Correction Strategy for Muscular Dystrophy Therapeutics

An improved gene correction strategy in muscle stem cells shows encouraging results in a mouse model of Duchene Muscular Dystrophy.

New Players in Wnt-mediated Control of Muscle Growth and Repair

Detailed assays delineate the muscle-specific mechanisms of Wnt signaling in muscle satellite cells through Barx2, Pax7 and myogenic factors, which may lead to strategies to enhance muscle growth and repair.

Improving the Therapeutic Relevance of Muscle Stem Cells

Sustained Release of Bone Morphogenetic Protein 2 via Coacervate Improves the Osteogenic Potential of Muscle-Derived Stem Cells

From Stem Cells Translational Medicine

The group of Johnny Huard at the University of Pittsburgh, USA have previously isolated and characterized muscle-derived stem cells (MDSCs) (Gharaibeh et al) which have been shown by various groups by be able to undergo osteogenic differentiation given the correct stimuli.   They are therefore a potential alternative to bone marrow-derived mesenchymal stem cells for bone tissue engineering.   One of these stimuli is continued exposure to BMPs, hindered by the short half-lives in vivo (Jeon et al and Zhao et al) and the requirement of maintaining a localised concentration.   The group have also devised a delivery strategy;  a poly(ethylene argininylaspartate diglyceride)(PEAD)-heparin complex loaded with BMP2 which forms an emulsion-like aggregation of organic molecules separated from the aqueous phase, or a coacervate (Johnson and Wang), previously used to effectively deliver fibroblast growth factor-2 (FGF2) for therapeutic angiogenesis (Chu et al).   Now, in a report in Stem Cells TM, they report on the use of this system with BMP2 to stimulate osteogenesis in MDSCs in vitro and in vivo (Li and Johnson et al).

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