Original article from STEM CELLS
"Preventive Cancer Stem Cell-Based Vaccination Reduces Liver Metastasis Development in a Rat Colon Carcinoma Syngeneic Model"
Cancer stem cells (CSCs) represent a minor population of self-renewing cells that fuel tumour growth and have recently been identified in solid tumors, including those in the colon (O'Brien et al, Ricci-Vitiani et al and Visvader and Lindeman). Colon carcinoma is the second most common cause of cancer-related morbidity due, in part, to the appearance of metastases in the liver in 50%–60% of patients (Steele and Ravikumar). In a recent study published in Stem Cells, researchers from the group of Valérie Pierrefite-Carle at the Université de Nice Sophia Antipolis, Nice, France, using a rat model of colon carcinoma, demonstrate that a preventive vaccination generated using a CSC lysate can protect against the development of this liver metastasis, suggesting that CSC-based vaccination could be an efficient treatment to reduce tumour relapse in colon carcinoma (Duarte and Momier et al).