Thrombopoietin Inhibits Murine Mast Cell Differentiation

Fabrizio Martelli, Barbara Ghinassi, Rodolfo Lorenzini, Alessandro M. Vannucchi, Rosa Alba Rana, Mitsuo Nishikawa, Sandra Partamian, Giovanni Migliaccio, Anna Rita Migliaccioa

ABSTRACT

We have recently shown that Mpl, the thrombopoietin receptor, is expressed on murine mast cells and on their precursors and that targeted deletion of the Mpl Gene increases mast cell Differentiation in mice. Here we report that treatment of mice with thrombopoietin or addition of this growth factor to bone marrow-derived mast cell cultures severely hampers the generation of mature cells from their precursors by inducing apoptosis. Analysis of the expression profiling of mast cells obtained in the presence of thrombopoietin suggests that thrombopoietin induces apoptosis of mast cells by reducing expression of the transcription factor Mitf and its target antiapoptotic gene Bcl2. Stem Cells 2008;26:912–919

Disclosure of potential conflicts of interest is found at the end of this article.

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