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Correlating Genome Topology and Gene Regulation during Reprogramming

Using an efficient and synchronous reprogramming system, researchers describe the dynamic alterations to genome topology, chromatin states, and gene expression

Stem Cells: License to be Pluripotent!

New research from the University of North Carolina establishes a link between rapid origin licensing and the maintenance of stem cell pluripotency

Highlighting Cell-Specific Paths of the Reprogramming Journey

Comparing the reprogramming of somatic cells of different sources helps researchers to delineate universal and cell-specific pieces of the reprogramming process

Universal CRISPR-Cas9 Mutation Correction Strategy in Human Pluripotent Stem Cells

Researchers describe how a new “universal” strategy for CRISPR-Cas9-mediated gene correction in patient derived stem cells may represent a promising therapeutic option

Surfen Towards Glycan-mediated Control of Embryonic Stem Cells

Researchers describe how modulating glycan-mediated growth factor association and signaling can maintain mESCs in a pluripotent state

Intact Cell Mass Spectrometry: Quality Control for Human Embryonic Stem Cells?

Researchers describe a robust and simple means to assess quality control in cultures of human embryonic stem cell cultures: intact cell mass spectrometry fingerprinting

Podocyte Comparison Highlights the Potential of Pluripotent Stem Cell-derived Kidney Organoids

New comparative study highlights the utility of human pluripotent stem cell-derived organoids in studies of kidney development and kidney disease

Conditional Knockout ESCs Reveal Cell Survival Role for Gabpa

A new study delineates the role of the tumor-related transcription factor Gabpa in the pluripotency network of mouse embryonic stem cells

New iPSC-model for Common Cause of Blindness Demonstrates Enormous Potential

A new study employs patient samples to develop a new induced pluripotent stem cell model of the dry form of age-related macular degeneration, a common cause of blindness

Application of New Human ESC Reporter Cell Line Enhances Differentiation of Important Retinal Cells

Researchers have improved the differentiation of RGCs by creating a new and improved reporter human ESC line generated via CRISPR/Cas9 genome editing 

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