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iPSC Production – Select Your Factors Wisely

More is not always better in reprogramming, as researchers show that a set of factors which reprogram cells with low efficiency are developmentally superior to other more “efficient” reprogramming cocktails.

Stem Cells Get Motoring!

Motor neuron diseases encompass a range of neurological disorders that affect the muscles and movement of the body. These disorders are caused by the progressive degeneration of motor neurons, often leading to paralysis and ultimately death in patients. Can a stem cell-based strategy provide replacement cells?

Link between the Proteasome and Pluripotency Further Strengthened

Researchers find Nrf2, a stress response gene, to be a pluripotency gene which mediates its effects through regulation of the proteasome

Human iPSC-Derived Neural Cells Form Extensive Neural Networks in Rodents

A new study finds that neural cells derived from human induced pluripotent stem cells can form an extensive axonal network in a rodent model

iPSC Model Links Neuropsychiatric-associated Genetic Defects to Synaptic Deficits

Scientists link a common mutation in patients with neuropsychiatric disorders to deregulated neuronal synapses through generating patient-specific induced pluripotent stem cells and following their differentiation

Neural Stem Cells from iPSCs – Not so Safe After All?

Researchers find that neural stem cells, but not terminally differentiated neural cell types, differentiated from iPSCs can revert to a pluripotent like state and potentially problematic for use in transplants.

Transgene Free iPSCs Yield Cells with Greater Functionality

Residual transgenes present after piggyBac-mediated human iPSC production affect the functionality of keratinocytes derived from such iPSCs compared to iPSCs completely free of transgene sequences

Towards the Clinical Implementation of ESC-derived Cardiac Cells

Using a non-human primate model, researchers demonstrate that sufficient numbers of human ESC-derived cardiomyocytes can be produced, stored, and transplanted, leading to good levels of engraftment and electrical coupling

Epigenetic Link to Cell Cycle Regulation in human ESCs

Histone demethylation through JMJD5 is found to be vital for the cell cycle and maintenance of pluripotency in embryonic stem cells

Reprogramming: The Prize for the Best Pluripotent Stem Cell Goes To………

Comparisons of genetically matched human pluripotent stem cells reveals that somatic cell nuclear transfer is the ideal means of generating cells for replacement therapy

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