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Pluripotency takes a Pause for Thought!

Researchers discover that modulation of a nutrient-sensing pathway can induce a “paused” state of pluripotency

Senescence - An Unexpected Helper for in vivo Reprogramming

New research into in vivo reprogramming highlights cellular senescence as an important regulator

iPSCs and Gene Correction Technology Team up to Tackle Beta Thalassemia

A new study demonstrates that the combination of iPSCs and gene correction technology may provide a patient-specific means to treat inherited blood disorders

Mapping Strategy Reveals Unexpected Landmarks in the Pluripotent Chromatin Landscape

A new mapping technique permits researchers to uncover unexpected findings regarding nucleosome occupancy in embryonic stem cells

Breaking down Epigenetic Barriers to iPSC Reprogramming

Researchers identify an epigenetic barrier to the production of induced pluripotent stem cells

Fluctuating Ahr Levels Control the Choice between Pluripotency and Differentiation

A new study highlights the important role of aryl hydrocarbon receptor in the regulation of the pluripotent state of mouse embryonic stem cells

MHC-matched iPSCs: The Way Forward for Regenerative Medicine?

Cardiomyocytes differentiated from MHC-matched but genetically dissimilar iPSCs can regenerate the damaged heart following myocardial infarction

ChIP-SICAP Reveals Pluripotency’s Secrets

A new ChIP-based technique permits the discovery of new and important factors which helps to maintain embryonic stem cell pluripotency

Success for iPSC-OPCs in a Non-human Primate Model of Multiple Sclerosis

A new study demonstrates the successful application of iPSC-derived oligodendrocyte precursor cells in a marmoset model of multiple sclerosis

Forget your Past for Enhanced Reprogramming!

Inhibiting BET protein function may help cells to forget their past and enhance the reprogramming of somatic cells into induced pluripotent stem cells

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