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STEM CELLS | STEM CELLS Translational Medicine
Generating inducible gene knockout in human pluripotent stem cells may open up a new level of understanding the roles of genes and groups of genes in pluripotency and differentiation.
Researchers demonstrate the pro-regenerative effects of exosomes derived from induced pluripotent stem cells and highlight a possible role for exosomes in tissue repair.
Neural progenitors derived from induced pluripotent stem cells are shown to reverse retinal degeneration and may represent an effective therapy to prevent the loss of vision
Researchers describe how a bacterial infection-based protein delivery strategy can mediate effective and safe gene editing in human pluripotent stem cells.
Researchers describe "region-selective" pluripotent stem cells from mouse and humans, and highlight their therapeutic potential.
A non-nucleic acid based reprogramming strategy promises to provide a safe and effective treatment for lost retinal cells in glaucoma sufferers.
Researchers use matched human embryonic stem cell lines to understand the perturbed developmental mechanisms which lead to heart defects in Down's Syndrome patients.
The implementation of mass cytometry analysis to the reprogramming process has illuminated the early chaotic stages of reprogramming and has uncovered essential new pathways controlling the process.
Researchers combine multiple stem/progenitor types to generate miniature functional organ “buds” which may be useful in developmental and disease modelling, and in the future, tissue replacement.
Gene editing technology, combined with iPSC generation and a clinically relevant differentiation strategy combine to offer a new treatment for a blood borne genetic disease
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