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Inducible Gene Knockouts in Human Stem Cells: CRISPR Hits the Headlines Again

Generating inducible gene knockout in human pluripotent stem cells may open up a new level of understanding the roles of genes and groups of genes in pluripotency and differentiation.

Microvesicles from Pluripotent Stem Cells Enhance Cardiac Regenerative Potential

Researchers demonstrate the pro-regenerative effects of exosomes derived from induced pluripotent stem cells and highlight a possible role for exosomes in tissue repair.

Patient-specific Neural Progenitor Therapy Preserves Visual Function

Neural progenitors derived from induced pluripotent stem cells are shown to reverse retinal degeneration and may represent an effective therapy to prevent the loss of vision

Can Engineered Bacteria Bring Gene-edited Human Stem Cells to the Clinic?

Researchers describe how a bacterial infection-based protein delivery strategy can mediate effective and safe gene editing in human pluripotent stem cells.

New Pluripotent Stem Cell Type with Enhanced Therapeutic Value Described

Researchers describe "region-selective" pluripotent stem cells from mouse and humans, and highlight their therapeutic potential.

Safer and Better? Alternative Reprogramming Technique Used for Glaucoma Cell Replacement Therapy

A non-nucleic acid based reprogramming strategy promises to provide a safe and effective treatment for lost retinal cells in glaucoma sufferers.

Understanding Heart Defects in Down's Syndrome using ESC Models

Researchers use matched human embryonic stem cell lines to understand the perturbed developmental mechanisms which lead to heart defects in Down's Syndrome patients.

Reprogramming Revealed Using a Mass-terly Strategy

The implementation of mass cytometry analysis to the reprogramming process has illuminated the early chaotic stages of reprogramming and has uncovered essential new pathways controlling the process.

Bud-ding New Strategy for Organ Formation Shows Success!

Researchers combine multiple stem/progenitor types to generate miniature functional organ “buds” which may be useful in developmental and disease modelling, and in the future, tissue replacement.

iPSCs and CRISPR - Daring Duo Combine to Fight Sickle Cell Disease

Gene editing technology, combined with iPSC generation and a clinically relevant differentiation strategy combine to offer a new treatment for a blood borne genetic disease


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