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Activating Progenitors Using Common Drugs to Treat Multiple Sclerosis

Two commonly used drugs are found to boost axonal remyelination in vivo and reverse symptoms in a mouse model of Multiple Sclerosis

Reversing Aging in the Brain?

Researchers begin to understand the molecular mechanisms behind the aging of stem cells in the brain and demonstrate the potential reversibility of age-related changes

ARHGAP11B - Key to the Development of the Human Brain?

Researchers discover a gene preferentially expressed in human neural progenitor cells whose expression promotes the appearance of human brain characteristics on mouse brans, and therefore may be the driving force behind human neocortex evolution and expansion

Engineering Stem Cells as an Effective Cancer Treatment

Application of doubly engineered neural stem cells proves to be a specific and highly effective method of removing remnant tumor mass after surgery

Spicing up the Control of Adult Neurogenesis

Researchers uncover a previously unknown role for chilli pepper-derived capsaicin receptor TRPV1 in the control of neural progenitor cell proliferation

Creating an Authentic Human Alzheimer’s Model

Researchers create a 3D model system of Alzheimer’s disease which fully recapitulates disease progression

Neural Progenitor Transplantation Leads to Functional Recovery in New Model of Spinal Cord Injury

Neural progenitor cell transplant in a new animal model for spinal cord injury suggests some functional recovery alongside a reduction in astrogliotic scarring

Neural Precursors Don’t Hang Around, But their Influence Lasts!

Neural progenitor cells derived from human embryonic stem cells can ameliorate the effect of virally-mediated inflammation and demyelination in a mouse model of multiple sclerosis.

Exercising a Defective Brain to Boost Neurogenesis

Studies using a mouse model find that exercise boosts neurogenesis by shortening the S-phase of the cell cycle in cells of the hippocampus, and uncovers an important role for the Btg1 gene in neural stem cell quiescence.

Biomaterial Support of Neurogenesis

Current methods of neural stem cell activation or recruitment are invasive and cause damage/inflammation and are poorly controlled. In order to circumnavigate these problems, researchers from University of California Berkeley have generated multivalent biomaterial forms of factors which improve neurogenesis, neurogenic differentiation and stem cell recruitment and show these to be highly effective in boosting neurogenesis in both neurogenic and non-neurogenic zones and, excitingly, show that multivalent biomaterials stop the decline in adult hippocampal neurogenesis which occurs during normal aging in rats.

  • Will this strategy work in other tissues?
  • Will this strategy allow for the repair of damage or degeneration?
  • Can we further boost these effects to overcome the hurdles outlines in the study?

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