Current methods of neural stem cell activation or recruitment are invasive and cause damage/inflammation and are poorly controlled. In order to circumnavigate these problems, researchers from University of California Berkeley have generated multivalent biomaterial forms of factors which improve neurogenesis, neurogenic differentiation and stem cell recruitment and show these to be highly effective in boosting neurogenesis in both neurogenic and non-neurogenic zones and, excitingly, show that multivalent biomaterials stop the decline in adult hippocampal neurogenesis which occurs during normal aging in rats.
- Will this strategy work in other tissues?
- Will this strategy allow for the repair of damage or degeneration?
- Can we further boost these effects to overcome the hurdles outlines in the study?