Pulp stem cells derived from human permanent and deciduous teeth: Biological characteristics and therapeutic applications
Xin Shi, et al., STEM CELLS Translational Medicine
Pulp stem cells can be readily harvested from dental pulp tissue of extracted permanent teeth and exfoliated deciduous teeth, respectively. However, a systematic and comprehensive review about pulp stem cells in terms of biological attributes and therapeutic applications is lacking. Accordingly, this review is concentrated on pulp stem cells to emphasize their updated biological characteristics such as cell markers, multipotency and origin, and promising therapeutic applications, including endodontic regeneration and extraoral tissue repair and regeneration, as well as rising cell bank with the intent of enhancing the understanding of dental mesenchymal stem cells and advancing associated tissue engineering and disease treatment.
Engraftment of skeletal progenitor cells by bone directed transplantation improves osteogenesis imperfecta murine bone phenotype
Benjamin P. Sinder, et al., STEM CELLS
A novel translational approach for the treatment of osteogenesis imperfecta (OI) using a murine model is presented. Attempts to treat OI using stem cells via systemic transplantation have not been successful. By direct intrabone transplantation of bone marrow stromal cells (also known as bone marrow‐derived mesenchymal stem cells), positive long‐term effects on bone microarchitecture and biomechanics were achieved. Using fluorescent genetic markers, donor stem cells and their ability to differentiate into mature cells of the osteoblast lineage—osteoblasts and osteocytes—were tracked. Engraftment persisted at least 6 months following transplantation, and cells show stem cell potential based on engraftment following secondary transplantation.
HDAC inhibitor-mediated expansion of HSCs derived from the peripheral blood and bone marrow of healthy adult donors may aid the development of safe and effective therapies
Researchers describe a novel strategy for the isolation of pure populations of subtype-specific cardiomyocytes from differentiating cultures of induced pluripotent stem cells
CRISPR-mediated negative selection screen in regenerating haploid axolotl limbs uncovers candidate genes crucial to the limb regeneration process