Featured Articles

Concise Review: Update on Retinal Pigment Epithelium Transplantation for Age-Related Macular Degeneration
STEM CELLS Translational Medicine

 

Cell-based therapy can be effective in chronic degenerative retinal disease, but the following obstacles must be addressed to optimize therapeutic efficacy: the abnormal microenvironment of the host, surgery-induced changes in the host retina, and the need for immune suppressive therapy for subretinal allogeneic retinal pigment epithelium (RPE) transplants.


FOXD3 Suppresses Tumor-Initiating Features in Lung Cancer Via Transcriptional Repression of WDR5
STEM CELLS

 

It is currently unclear whether FOXD3 plays any role in the tumor-initiating cells (TIC) and tumor metastasis. This study found that FOXD3 repressed TIC expansion and cell migration, drug resistance, and osteoclasts in vitro and in vivo. Mechanically, it was found that FOXD3 represses WDR5, which regulates the TIC-related signaling pathway. Collectively, the work defined that FOXD3 may suppress TIC accumulation by repressing the expression of WDR5 in lung cancer.

 

Article Scans

Trial of allogeneic MSC infusion before removal of the cancerous prostate establishes that cells do not home to primary tumor sites in sufficient levels

High-throughput Integrated Fluidic Circuits for single-cell RNA sequencing describes embryonic stem cell‐derived retinal organoids during differentiation

An innovative mobile skin bioprinting system integrates wound imaging with precise in-situ cell delivery to accelerate skin formation and wound healing