Regenerative Medicine Manufacturing Society (RMMS) is partnering with STEM CELLS Translational Medicine to build a freely accessible collection of shared resources across three areas: models; cell therapies; and technologies. These resources will bring together the scientific community and highlight how the field of regenerative medicine is uniquely positioned to fight the COVID-19 pandemic.
Featured Articles - February 17, 2021
Synergistic effect of nanofat and mouse nerve‐growth factor for promotion of sensory recovery in anterolateral thigh free flaps
Shune Xiao, et al., STEM CELLS Translational Medicine
Nanofat and mouse nerve growth factor (mNGF) had a synergistic effect on sensory recovery of anterolateral thigh (ALT) free flaps that was associated with stimulation of angiogenesis and neurogenesis. The results provide a theoretical rationale for further study of the clinical use of nanofat combined with mNGF to promote the sensory recovery of ALT free flaps.
Cell therapy in Huntington's disease: Taking stock of past studies to move the field forward
Anne‐Catherine Bachoud‐Lévi, et al., STEM CELLS
Cell therapy is the only approach currently focused on structural and functional restoration in Huntington's disease. The lack of benefit shown in the largest fetal cell transplant trial to date, the multicenter intracerebral transplant in Huntington's disease trial (MIG‐HD), cautions against uncontrolled cell therapy treatments. However, MIG‐HD resulted in new procedures that significantly improved patient safety and enlightened upcoming cell transplant protocols. Stem cells should dramatically change the landscape by permitting better control of the quantity and homogeneity of the donor cell product. This study proposes ways to improve future trials, thereby increasing their chance for success.
A multimaterial scaffold combined with Wharton’s jelly-derived MSCs exhibit huge promise in the treatment of critical-sized bone defects
Bone marrow-derived leptomeningeal myeloid progenitors may provide a platform for a better understanding of CNS surveillance and local immune cell production
A small-molecule compound that activates mitochondrial respiration can rescue defects to neuronal differentiation in iPSCs carrying mutant mitochondrial DNA