The leaky blood‐brain barrier in niches of the intact and stroke brain can respond to circulating VEGF165 to drive neural stem cells (NSCs) activation and neurogenesis. Vascular endothelial growth factor (VEGF165) induces expression of the Notch ligand DLL4 in endothelial cells, pericytes, after stroke or oxygen‐glucose deprivation. The enhanced DLL4‐Notch signaling and crosstalk between vasculature cells and NSCs regulate the activities of NSCs when triggered by systemic stroke‐induced factors.
Given the nature of stem cell therapy, it is impossible to be certain that a tumorigenic transformation will not occur following transplantation. However, clinicians/scientists are duty‐bound to tackle the issue from multiple angles, working toward clinical implementation of this novel technology. Previous studies, aiming to tackle tumorigenesis after the transplantation has been performed, involved the eradication of all of the transplanted cells and the loss of the improved motor function as a result. This new approach, however, allows us to both prevent and treat tumorigenesis that occur post‐transplantation without sacrificing the improved motor function which is definitely an improvement worth noting.
Researchers discover enhanced liver repair following treatment with mesenchymal stem cells and stimulated macrophages in a mouse model of cirrhosis