A pre-investigational new drug study of lung spheroid cell therapy for treating pulmonary fibrosis
Jhon Cores , et al., STEM CELLS Translational Medicine
This study helps set the stage for the transition of this cellular therapy paradigm from rodent models to clinical trials in a number of ways. The transbronchial acquisition of the lung spheroid cells is a minimally invasive strategy suitable for the clinic and preferable to thoracoscopic alternatives; the doses used in this study are scalable, manufacturable, and comparable to currently existing clinical trial efforts targeting other lung diseases; and the intravenous route of administration used is applicable to clinical trials, as it presents an easy, quick, and patient-friendly way to administer the treatment.
Subtype-specific cardiomyocytes for precision medicine: Where are we now?
Ming‐Tao Zhao , et al., STEM CELLS
This review summarizes the recent progress on how to generate chamber-specific cardiomyocytes from human pluripotent stem cells from the perspective of developmental biology. Precise generation of atrial-, ventricular-, and pacemaker-like cardiomyocytes will greatly facilitate the translational applications of patient-derived induced pluripotent stem cells.
New research shows how MSC-secreted factors can impair biofilm formation by cutaneous wound‐related bacteria and disrupt mature biofilms via a protease‐dependent mechanism
Lin28-mediated conversion of inner-ear glia into neurons represents a new approach to the replacement of lost/damaged auditory nerves and the reversal of hearing loss
New research finds that overexpression of Myc and a transcription elongation factor promotes cardiomyocyte proliferation in the adult mouse heart