Featured Articles

A Five-Year Study of the Efficacy of Purified CD34+ Cell Therapy for Angiitis-Induced No-Option Critical Limb Ischemia

Long-term efficacy and durability of autologous transplantation of purified CD34+ cells was shown for the treatment of angiitis-induced no-option critical limb ischemia, including achievement of ideal limb salvage, recovery of labor competence, and improved quality of life.

Reduction of Fibrosis and Scar Formation by Partial Reprogramming In Vivo

Cellular reprogramming by activation of OCT4, SOX2, KLF4, and C-MYC (OSKM) transcription factors has recently been discussed as a strategy for regenerating damaged tissues in vivo. The effects of OSKM factors on wound healing in a mouse model have been tested. The study results showed that in situ expression of OSKM factors during wound healing diminishes fibrotic activity and leads to a reduction in scar tissue formation. This study proposes that partial reprogramming by transient induction of OSKM factors could be used as a powerful tool for enhancing scar-reduced regeneration of injured tissues, and it should be further explored as a potential treatment for fibrotic organ diseases.


Journal Club Discussions

August 20, 2018

A novel compound that increases neurogenesis in the hippocampus may represent a new means to treat hippocampus-associated cognitive dysfunction



Article Scans

August 20, 2018
Researchers employ pneumatic 3D extrusion bioprinting to generate bona fide biological corneal structures for regenerative medicine applications
August 20, 2018
Researchers comparing hematopoietic stem cells from various sources establish an advantage of freshly-isolated cells over in vitro expanded cells
August 13, 2018
Trial results suggest that the intravenous infusion of UCB represents a non-invasive, safe, and feasible means to treat acute ischemic stroke