Mesenchymal stromal/stem cells (MSCs) have been used for treatment of ischemic diseases. However, their inconsistent potency due to donor or source variation and culture condition has been a problem in clinical application. To find biomarkers of MSCs for predicting vascular regenerative potency, this study aimed to find correlations of secretion profile of paracrine factors with in vitro and in vivo proangiogenic activities. Four major factors (angiogenin, interleukin‐8, monocyte chemoattractant protein‐1, and vascular endothelial growth factor) were found to be efficient biomarkers for predicting vascular regenerative efficacy in the treatment of ischemic diseases.
Leydig stem cell autograft is a novel therapeutic approach to increase serum testosterone while simultaneously preserving testicular function. By optimizing the protocol, a safe and effective treatment can be developed for men with low testosterone who desire fertility preservation. The potential impact of Leydig stem cell autograft as a therapy to increase testosterone could be paradigm shifting for the clinical treatment of low testosterone.
Researchers show how the inhibition of a DNA repair mediator may represent an exciting means to potentiate chemotherapy in colorectal cancer patients