Cellular reprogramming by activation of OCT4, SOX2, KLF4, and C-MYC (OSKM) transcription factors has recently been discussed as a strategy for regenerating damaged tissues in vivo. The effects of OSKM factors on wound healing in a mouse model have been tested. The study results showed that in situ expression of OSKM factors during wound healing diminishes fibrotic activity and leads to a reduction in scar tissue formation. This study proposes that partial reprogramming by transient induction of OSKM factors could be used as a powerful tool for enhancing scar-reduced regeneration of injured tissues, and it should be further explored as a potential treatment for fibrotic organ diseases.
Long-term efficacy and durability of autologous transplantation of purified CD34+ cells was shown for the treatment of angiitis-induced no-option critical limb ischemia, including achievement of ideal limb salvage, recovery of labor competence, and improved quality of life.
A novel compound that increases neurogenesis in the hippocampus may represent a new means to treat hippocampus-associated cognitive dysfunction