Regenerative Medicine Manufacturing Society (RMMS) is partnering with STEM CELLS Translational Medicine to build a freely accessible collection of shared resources across three areas: models; cell therapies; and technologies. These resources will bring together the scientific community and highlight how the field of regenerative medicine is uniquely positioned to fight the COVID-19 pandemic.
Featured Articles - October 19, 2020
Magnetic targeting increases mesenchymal stromal cell retention in lungs and enhances beneficial effects on pulmonary damage in experimental silicosis
Luisa H. A. Silva, et al., STEM CELLS Translational Medicine
Although systemic administration of mesenchymal stromal cells (MSCs) ameliorates lung inflammation and attenuates fibrosis in experimental silicosis, it does not reverse collagen deposition and granuloma formation. This study established an MSC magnetization protocol using citrate functionalized magnetic nanoparticles that kept cells viable and made them magnetically responsive. With the aid of magnets, more magnetized MSCs remained in the lungs, and this was associated with enhanced beneficial effects for the treatment of silicosis in mice. Magnetic targeting may be a promising strategy for enhancing the beneficial effects of MSC‐based cell therapies for silicosis and other chronic lung diseases.
Enhanced collection of phenotypic and engrafting human cord blood hematopoietic stem cells at 4°C
Hal E. Broxmeyer, et al., STEM CELLS
The number of hematopoietic stem cells (HSCs) collected in cord blood (CB) at the birth of a baby is a limiting factor for efficacious use of CB in hematopoietic cell transplantation (HCT). We now demonstrate that collecting and processing of human CB at 4°C within minutes of the baby's birth results in significantly enhanced numbers of rigorously defined phenotypic HSC and self‐renewing NSG immune‐deficient mouse engrafting and SCID‐repopulating cells. This was associated with decreased numbers of hematopoietic progenitor cells (HPC), as noted previously for hypoxia collected/processed cells blocking ambient air induced differentiation of HSC to HPC. We have thus defined a simple, cost‐effective, means to collect increased numbers of CB HSC, of potential use for clinical CB HCT.
A new study reports the intrinsic neurotrophic properties of decellularized scaffolds, thereby supporting their application in muscle regeneration approaches
The processing of cord blood under lower-than-normal temperatures enhances the numbers of phenotypically and functionally defined self‐renewing HSCs
Researchers use induced pluripotent stem cells grown and differentiated within an extracellular matrix bioink to develop a chambered muscle pump