Body: Researchers developed a biomaterial using stem cells aiming to reverse a condition called intervertebral disk (IVD) degeneration, which is associated with back pain and certain spinal issues. The stem cells were induced into chondrocytes -- cells producing collagen that supports cartilage tissue. Implanting this biomaterial into a rat model of IVD degeneration brought the spinal mechanical properties back to control levels. This could be crucial for regenerative medicine to reverse this painful back problem.
Body: Researchers want to improve their understanding of the immune environment in ovarian cancer in hopes of making immunotherapy an option for these patients. Researchers now report on key characteristics of immune cells in ovarian cancer and identify cell types important for mediating an immune response.
Body: Scientists have created a new roadmap that traces each step in the development of blood stem cells in the human embryo, providing scientists with a blueprint for producing fully functional blood stem cells in the lab. The research could help expand treatment options for blood cancers like leukemia and inherited blood disorders such as sickle cell disease.
Body: Curcumin, a compound found in turmeric, has anti-inflammatory and antioxidant properties and is known to suppress angiogenesis in malignant tumors. Bioengineers have now discovered that when delivered through magnetic hydrogels into stem cell cultures this versatile compound paradoxically also promotes the secretion of vascular endothelial growth factor, or VEGF, that helps vascular tissues grow.
Body: Tissues often fail to regenerate from traumatic muscle-loss injuries such as gunshot wounds and car accidents, and new research in mice sheds light on why.
Body: Although clinical labs have known for almost a century that a oddly shaped nucleus resembling pince-nez glasses in blood cells could indicate leukemia, the cause of this anomaly remained unknown. Scientists have now discovered that loss of nuclear Lamin B1 induces defects in the nuclear morphology and in human hematopoietic [blood-forming] stem cells associated with malignancy. The scientists went on to detail that lamin B1 deficiency alters genome organization. This in turn causes expansion of blood-forming stem cells, a bias towards their becoming myeloids, genome instability due to defective DNA damage repair and other problems that set the stage for cancer.
Body: The SARS-CoV-2 virus can infect specialized pacemaker cells that maintain the heart's rhythmic beat, setting off a self-destruction process within the cells, according to a preclinical study. The findings offer a possible explanation for the heart arrhythmias that are commonly observed in patients with SARS-CoV-2 infection.
Body: Stem cells can develop into many different types of cells in the body. For instance, when a person is injured, stem cells come to the site of the injury and aid in healing damaged tissues. New nanotechnology could leverage the body's regenerative potential by directing stem cells to form bone tissue.
Body: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects as many as 30,000 people in the United States, with 5,000 new cases diagnosed each year. It weakens muscles over time, impacting physical function and ultimately leading to death. There is no single cause for the disease and no known cure. However, researchers have found a possible window of opportunity during ALS treatment to target astrocyte abnormalities.
Body: Researchers have identified key factors that promote the reprogramming of human stem cells to the naïve state, which can be used to model the earliest stages of development. This new knowledge will help researchers to generate naïve pluripotent stem cells more efficiently and quickly. Their findings also provide new insights into the mechanisms that destabilise and reconfigure cell identity during cell state transitions.