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March 22, 2022
Body: Investigators have created specialized, tissue-like structures in the laboratory to model barrier tissues, such as the intestines, to identify new targets for treatment.
March 18, 2022
Body: Tracing the impact of a single protein, Piezo1, researchers found that restoring it in muscles affected by Duchenne muscular dystrophy could improve their ability to heal efficiently.
March 16, 2022
Body: Scientists have 3D printed human testicular cells and identified promising early signs of sperm-producing capabilities. The researchers hope the technique will one day offer a solution for people living with presently untreatable forms of male infertility.
March 15, 2022
Body: Fusing human retinal cells with adult stem cells could be a potential therapeutic strategy to treat retinal damage and visual impairment, according to the findings of a new study. The hybrid cells were injected into a growing retinal organoid, a model that closely resembles the function of the human retina. The researchers found that the hybrid cells successfully engrafted into the tissue and differentiated into cells that closely resemble ganglion cells, a type of neuron essential for vision. The hybrid cells act by awakening the regenerative potential of human retinal tissue, previously only thought to be the preserve of cold-blood vertebrates.
March 8, 2022
Body: A single protein can reverse the developmental clock on adult brain cells called astrocytes, morphing them into stem-like cells that produce neurons and other cell types, UT Southwestern researchers report in a new study. The findings might someday lead to a way to regenerate brain tissue after disease or injury.
March 7, 2022
Body: One of the most promising approaches to replacing sick or damaged cells with healthy cells is cellular reprogramming, whereby one cell type in our body converts to another cell type. Research has uncovered new ways to improve the cellular reprogramming efficiency, unlocking potential for cellular repair therapies.
March 3, 2022
Body: Insulin is a vital hormone produced by pancreatic beta cells. Type 1 diabetes is caused by the destruction of these cells, which results in patients having to replace the lost insulin with multiple daily injections.
March 3, 2022
Body: People are having children later than ever before. The average age of new parents in the United States has been rising for at least the past half century. But time is tough on our bodies and our reproductive systems. For instance, as animals age, our stem cells are less effective at renewing our tissues. This is particularly true for germline stem cells, which turn into sperm and eggs. What if there were a way to pause this process?
March 1, 2022
Body: Hematopoietic stem cells can grow and make healthy blood cells after being transplanted into patients with blood cell--related diseases. Researchers have now revealed the unique signature of genes expressed by these cells. The findings could enable scientists to expand these cells or to convert other types of cells into cells that can repopulate the blood system, which would have important clinical applications. This work could facilitate treatment of multiple diseases or allow the creation of a limitless supply of these rare cells from other more common cell types in the future.
February 24, 2022
Body: Divide, differentiate or die? Making decisions at the right time and place is what defines a cell's behavior and is particularly critical for stem cells of an developing organisms. Decision making relies on how information is processed by networks of signaling proteins. Scientists have now revealed that ERK, a key player in stem cell signaling, processes information through fast activity pulses. The duration of the pulsing interval, might encode information essential for divergent fate decision in stem cell cultures.