Body: Scientists have found a way to prove that biochemical signals sent from cell to cell play an important role in determining how those cells develop, findings that can help explain how stem cells differentiate and how cancer arises and proliferates, possibly leading to new treatments.
Body: Researchers have shown, in a small clinical trial, that an immunotherapy harnessing pre-activated natural killer cells can help some children and young adults with recurrent AML and few other treatment options.
Body: An experimental gene therapy for sickle cell disease restored blood cells to their normal shape and eliminated severe pain crises for years after treatment, a multicenter study has found.
Body: In a study of mice, scientists showed how the activity of one gene, turned on in a newly discovered group of bone-bordering cells, may play an important role in shaping the skull. The skulls of mice that were missing the gene were misshapen and were depleted of the cells in a manner that is reminiscent of craniosynostosis, a developmental disorder that affects about one out every 2,500 babies born in the United States.
Body: New research reveals how our immune cells use the body's fat stores to fight infection. The research could help develop new approaches to treating people with bacterial infections. And the team say their work could one day help treat infections in vulnerable and older people.
Body: If one of your parents majored in a STEM (science, technology, engineering or math) field, there's a better chance you'll also major and persist in a STEM field, according to a new study.
Body: Interim results from a multicenter clinical trial demonstrate insulin secretion from engrafted cells in patients with type 1 diabetes. The safety, tolerability, and efficacy of the implants, which consisted of pancreatic endoderm cells derived from human pluripotent stem cells (PSCs), were tested in 26 patients. While the insulin secreted by the implants did not have clinical effects in the patients, the data are the first reported evidence of meal-regulated insulin secretion by differentiated stem cells in human patients.
Body: Researchers have developed a method to precisely and rapidly correct genetic alterations in the cultured patient cells.
Body: Obesity, diabetes and gastrointestinal cancer are frequently linked to an unhealthy diet. However, the molecular mechanisms responsible for this are not fully understood. Researchers have gained some new insights that help to better understand this connection. These findings provide an important basis for the development of non-invasive therapies.
Body: Scientists have used glowing chemicals and other techniques to create a 3D map of the blood vessels and self-renewing 'stem' cells that line and penetrate a mouse skull. The map provides precise locations of blood vessels and stem cells that scientists could eventually use to repair wounds and generate new bone and tissue in the skull.