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Enhancing T cell development from HSPCs with Physioxia

A recent study from the laboratory of Hal. E. Broxmeyer (Indiana University School of Medicine, Indianapolis, IN, USA) describes the effect of physiologically relevant oxygen concentration (5% O2, physioxia) on T cell differentiation and maturation from human hematopoietic stem and progenitor cells (HSPCs). Shin et al. demonstrate that physioxia promotes HSC commitment and HPC differentiation into progenitor/precursor T cells in suspension culture; furthermore, the potent antioxidant ascorbic acid enhances this effect and facilitates T cell maturation in artificial thymic organoids. Overall, this new STEM CELLS article provides new insight into human T cell development, which may be useful for future clinical translation for patients undergoing cord blood HSC transplantation and for immunocompromised patients.