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Volume 32, Issue 1 - January 2014

Editorial

Editorial: 2013—A Year of Clinical Success and Great Scientific Innovation in the Stem Cell Field (pages 1–2)
Jan A. Nolta
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1602

Embryonic Stem Cells/Induced Pluripotent Stem Cells

Concise Review: Harmonies Played by MicroRNAs in Cell Fate Reprogramming(pages 3–15)
Sharif Moradi, Sassan Asgari and Hossein Baharvand
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1576

Regenerative Medicine

Concise Review: Current Status of Stem Cells and Regenerative Medicine in Lung Biology and Diseases (pages 16–25)
Daniel J. Weiss
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1506

Concise Review: Hurdles in a Successful Example of Limbal Stem Cell-based Regenerative Medicine (pages 26–34)
Graziella Pellegrini, Paolo Rama, Antonio Di Rocco, Athanasios Panaras and Michele De Luca
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1517

Concise Review: Bridging the Gap: Bone Regeneration Using Skeletal Stem Cell-Based Strategies—Where Are We Now? (pages 35–44)
Jonathan I. Dawson, Janos Kanczler, Rahul Tare, Moustapha Kassem and Richard O.C. Oreffo
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1559

Tissue-Specific Stem Cells

Pax6 Mediates ß-Catenin Signaling for Self-Renewal and Neurogenesis by Neocortical Radial Glial Stem Cells (pages 45–58)
Qini Gan, Albert Lee, Ryusuke Suzuki, Takashi Yamagami, Arjun Stokes, Bao Chau Nguyen, David Pleasure, Junjiang Wang, Hong-Wu Chen and Chengji J. Zhou
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1561

The Subventricular Zone Is Able to Respond to a Demyelinating Lesion After Localized Radiation (pages 59–69)
Vivian Capilla-Gonzalez, Hugo Guerrero-Cazares, Janice M. Bonsu, Oscar Gonzalez-Perez, Pragathi Achanta, John Wong, Jose Manuel Garcia-Verdugo and Alfredo Quiñones-Hinojosa
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1519

Molecular Diversity Subdivides the Adult Forebrain Neural Stem Cell Population(pages 70–84)
Claudio Giachino, Onur Basak, Sebastian Lugert, Philip Knuckles, Kirsten Obernier, Roberto Fiorelli, Stephan Frank, Olivier Raineteau, Arturo Alvarez-Buylla and Verdon Taylor
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1520

Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing β-Catenin(pages 85–92)
Gozde Yucel, John Van Arnam, Paula Casey Means, Erik Huntzicker, Banu Altindag, Maria Fernanda Lara, Jenny Yuan, Calvin Kuo and Anthony E. Oro
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1525

Generation of Functional, Antigen-Specific CD8+ Human T Cells from Cord Blood Stem Cells Using Exogenous Notch and Tetramer-TCR Signaling (pages 93–104)
Irina Fernandez, Tracy P. Ooi and Krishnendu Roy
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1512

Wnt5a Regulates Hematopoietic Stem Cell Proliferation and Repopulation Through the Ryk Receptor (pages 105–115)
Benjamin J. Povinelli and Michael J. Nemeth
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1513

Translational and Clinical Research

Human Mesenchymal Stem Cell Microvesicles for Treatment of Escherichia coliEndotoxin-Induced Acute Lung Injury in Mice (pages 116–125)
Ying-gang Zhu, Xiao-mei Feng, Jason Abbott, Xiao-hui Fang, Qi Hao, Antoine Monsel, Jie-ming Qu, Michael A. Matthay and Jae W. Lee
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1504

Cancer Stem Cells

Two Novel Splice Variants of SOX2OT, SOX2OT-S1, and SOX2OT-S2 are Coupregulated with SOX2 and OCT4 in Esophageal Squamous Cell Carcinoma(pages 126–134)
Alireza Shahryari, Mahmoud Reza Rafiee, Youssef Fouani, Nasrin Alipour Oliae, Nader Mansour Samaei, Mohammad Shafiee, Shahryar Semnani, Mohammad Vasei and Seyed Javad Mowla
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1542

The RNA-Binding Protein Musashi-1 Regulates Proteasome Subunit Expression in Breast Cancer- and Glioma-Initiating Cells (pages 135–144)
Chann Lagadec, Erina Vlashi, Patricia Frohnen, Yazeed Alhiyari, Mabel Chan and Frank Pajonk
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1537

CD44 Expressed on Cancer-Associated Fibroblasts Is a Functional Molecule Supporting the Stemness and Drug Resistance of Malignant Cancer Cells in the Tumor Microenvironment (pages 145–156)
Yumi Kinugasa, Takahiro Matsui and Nobuyuki Takakura
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1556

Embryonic Stem Cells/Induced Pluripotent Stem Cells

Oct4 Maintains the Pluripotency of Human Embryonic Stem Cells by Inactivating p53 Through Sirt1-Mediated Deacetylation (pages 157–165)
Zhen-Ning Zhang, Sun-Ku Chung, Zheng Xu and Yang Xu
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1532

Vitamin C Enhances Nanog Expression Via Activation of the JAK/STAT Signaling Pathway (pages 166–176)
Haibo Wu, Yongyan Wu, Zhiying Ai, Liping Yang, Yuan Gao, Juan Du, Zekun Guo and Yong Zhang
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1523

Akt Suppression of TGFβ Signaling Contributes to the Maintenance of Vascular Identity in Embryonic Stem Cell-Derived Endothelial Cells (pages 177–190)
Edo Israely, Michael Ginsberg, Daniel Nolan, Bi-Sen Ding, Daylon James, Olivier Elemento, Shahin Rafii and Sina Y. Rabbany
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1521

Expression of Podocalyxin Separates the Hematopoietic and Vascular Potentials of Mouse Embryonic Stem Cell-Derived Mesoderm (pages 191–203)
Hailan Zhang, Johnathan L. Nieves, Stuart T. Fraser, Joan Isern, Panagiotis Douvaras, Dmitri Papatsenko, Sunita L. D'Souza, Ihor R. Lemischka, Michael A. Dyer and Margaret H. Baron
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1536

Critical Components of the Pluripotency Network Are Targets for the p300/CBP Interacting Protein (p/CIP) in Embryonic Stem Cells (pages 204–215)
J.M. Chitilian, G. Thillainadesan, J.L. Manias, W.Y. Chang, E. Walker, M. Isovic, W.L. Stanford and J. Torchia
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1564

Regenerative Medicine

Nanotubular Crosstalk with Distressed Cardiomyocytes Stimulates the Paracrine Repair Function of Mesenchymal Stem Cells (pages 216–230)
Florence Figeac, Pierre-François Lesault, Olivier Le Coz, Thibaud Damy, Richard Souktani, Céline Trébeau, Alain Schmitt, Jonathan Ribot, Rémi Mounier, Aurélie Guguin, Céline Manier, Mathieu Surenaud, Luc Hittinger, Jean-Luc Dubois-Randé and Anne-Marie Rodriguez
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1560

HIF-Prolyl Hydroxylase 2 Inhibition Enhances the Efficiency of Mesenchymal Stem Cell-Based Therapies for the Treatment of Critical Limb Ischemia (pages 231–243)
Kiave-Yune HoWangYin, Céline Loinard, Wineke Bakker, Coralie L. Guérin, José Vilar, Clément D'Audigier, Laetitia Mauge, Patrick Bruneval, Joseph Emmerich, Bernard I. Lévy, Jacques Pouysségur, David M. Smadja and Jean-Sébastien Silvestre
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1540

Generation of Neuronal Progenitor Cells in Response to Tumors in the Human Brain (pages 244–257)
Jadranka Macas, Min-Chi Ku, Christian Nern, Yuanzhi Xu, Helmut Bühler, Marc Remke, Michael Synowitz, Kea Franz, Volker Seifert, Karl H. Plate, Helmut Kettenmann, Rainer Glass and Stefan Momma
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1581

Stem Cell Technology: Epigenetics, Genomics, Proteomics, and Metabonomics

Surfaceome Profiling Reveals Regulators of Neural Stem Cell Function (pages 258–268)
Brian DeVeale, Damaris Bausch-Fluck, Raewyn Seaberg, Susan Runciman, Vahe Akbarian, Phillip Karpowicz, Charles Yoon, Hannah Song, Rachel Leeder, Peter W. Zandstra, Bernd Wollscheid and Derek van der Kooy
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1550

Differential Sensitivity to JAK Inhibitory Drugs by Isogenic Human Erythroblasts and Hematopoietic Progenitors Generated from Patient-Specific Induced Pluripotent Stem Cells (pages 269–278)
Zhaohui Ye, Cyndi F. Liu, Lucie Lanikova, Sarah N. Dowey, Chaoxia He, Xiaosong Huang, Robert A. Brodsky, Jerry L. Spivak, Josef T. Prchal and Linzhao Cheng
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1545

Histone Deacetylase Inhibition with Valproic Acid Downregulates Osteocalcin Gene Expression in Human Dental Pulp Stem Cells and Osteoblasts: Evidence for HDAC2 Involvement (pages 279–289)
Francesca Paino, Marcella La Noce, Virginia Tirino, Pasqualina Naddeo, Vincenzo Desiderio, Giuseppe Pirozzi, Alfredo De Rosa, Luigi Laino, Lucia Altucci and Gianpaolo Papaccio
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1544

Translational and Clinical Research

TLR Ligands Stimulation Protects MSC from NK Killing (pages 290–300)
Massimo Giuliani, Annelise Bennaceur-Griscelli, Arash Nanbakhsh, Noufissa Oudrhiri, Salem Chouaib, Bruno Azzarone, Antoine Durrbach and Jean-Jacques Lataillade
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1563

A High Notch Pathway Activation Predicts Response to γ Secretase Inhibitors in Proneural Subtype of Glioma Tumor-Initiating Cells (pages 301–312)
Norihiko Saito, Jun Fu, Siyuan Zheng, Jun Yao, Shuzhen Wang, Diane D. Liu, Ying Yuan, Erik P. Sulman, Frederick F. Lang, Howard Colman, Roel G. Verhaak, W. K. Alfred Yung and Dimpy Koul
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1528

Pten Loss in Olig2 Expressing Neural Progenitor Cells and Oligodendrocytes Leads to Interneuron Dysplasia and Leukodystrophy (pages 313–326)
Cécile L. Maire, Shakti Ramkissoon, Marika Hayashi, Sam Haidar, Lori Ramkissoon, Emmanuelle DiTomaso and Keith L. Ligon
Article first published online: 3 JAN 2014 | DOI: 10.1002/stem.1590